Joseph W Lewcock
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Explore the profile of Joseph W Lewcock including associated specialties, affiliations and a list of published articles.
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55
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2469
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Recent Articles
1.
Khoury N, Pizzo M, Discenza C, Joy D, Tatarakis D, Todorov M, et al.
Nat Commun
. 2025 Feb;
16(1):1822.
PMID: 39979268
Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased...
2.
Paolo G, Lewcock J
Neuron
. 2025 Feb;
113(4):501-503.
PMID: 39978312
A microglia subpopulation termed "dark microglia" has been associated with aging and neurodegeneration, although its role has remained elusive. New research from Flury et al. in this issue of Neuron...
3.
Guo J, Braun D, Fitzgerald G, Hsieh Y, Rouge L, Litvinchuk A, et al.
Cell
. 2024 Nov;
188(1):187-206.e26.
PMID: 39532095
While apolipoprotein E (APOE) is the strongest genetic modifier for late-onset Alzheimer's disease (LOAD), the molecular mechanisms underlying isoform-dependent risk and the relevance of ApoE-associated lipids remain elusive. Here, we...
4.
Yulyaningsih E, Suh J, Fanok M, Chau R, Solanoy H, Takahashi R, et al.
Elife
. 2024 Sep;
12.
PMID: 39287504
The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although acute activation of this pathway restores...
5.
Barker S, Thayer M, Kim C, Tatarakis D, Simon M, Dial R, et al.
Sci Transl Med
. 2024 Aug;
16(760):eadi2245.
PMID: 39141703
Antisense oligonucleotides (ASOs) are promising therapeutics for treating various neurological disorders. However, ASOs are unable to readily cross the mammalian blood-brain barrier (BBB) and therefore need to be delivered intrathecally...
6.
Reich M, Simon M, Polke B, Paris I, Werner G, Schrader C, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadj7308.
PMID: 38838131
Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43) pathology (FTLD-). Multiple therapeutic strategies are in clinical development to restore PGRN...
7.
Craig 2nd R, De Vicente J, Estrada A, Feng J, Lexa K, Canet M, et al.
J Med Chem
. 2024 Mar;
67(7):5758-5782.
PMID: 38511649
Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress response (ISR), which regulates protein synthesis and stress granule formation in response to cellular insult. Modulation...
8.
Logan T, Simon M, Rana A, Cherf G, Srivastava A, Davis S, et al.
Cell
. 2024 Mar;
187(6):1565-1566.
PMID: 38490183
No abstract available.
9.
Miyamoto T, Kim C, Chow J, Dugas J, DeGroot J, Bagdasarian A, et al.
J Biol Chem
. 2024 Jan;
300(2):105630.
PMID: 38199568
Sterile alpha and toll/interleukin receptor motif-containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD following injury. Recent work has defined the mechanisms underlying...
10.
Benatar M, Ostrow L, Lewcock J, Bennett F, Shefner J, Bowser R, et al.
Ann Neurol
. 2023 Dec;
95(2):211-216.
PMID: 38110839
Objective: To explore whether the utility of neurofilament light chain (NfL), as a biomarker to aid amyotrophic lateral sclerosis (ALS) therapy development, would be enhanced by obtaining formal qualification from...