Thomas L Leto
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Explore the profile of Thomas L Leto including associated specialties, affiliations and a list of published articles.
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68
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2439
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Recent Articles
1.
Knaus U, Clark R, Nauseef W, Dinauer M, Leto T, Jaquet V
Immunity
. 2024 Aug;
57(8):1716-1718.
PMID: 39142268
No abstract available.
2.
Desai J, Zarakas M, Wishart A, Roschewski M, Aufiero M, Donko A, et al.
J Clin Invest
. 2024 May;
134(12).
PMID: 38696257
We describe a previously unappreciated role for Bruton's tyrosine kinase (BTK) in fungal immune surveillance against aspergillosis, an unforeseen complication of BTK inhibitors (BTKi) used for treating B cell lymphoid...
3.
Hall G, Donko A, Pratt C, Kim-Chang J, Martin P, Stallings A, et al.
Front Pediatr
. 2024 Mar;
12:1365187.
PMID: 38516355
We report the case of a 1-week-old male born full-term, who had two inconclusive severe combined immunodeficiency (SCID) newborn screens and developed scalp cellulitis and bacteremia. He did not pass...
4.
Donko A, Sharapova S, Kabat J, Ganesan S, Hauck F, Bergerson J, et al.
Blood
. 2024 Jan;
143(15):1476-1487.
PMID: 38194689
Mutations in the small Rho-family guanosine triphosphate hydrolase RAC2, critical for actin cytoskeleton remodeling and intracellular signal transduction, are associated with neonatal severe combined immunodeficiency (SCID), infantile neutrophilic disorder resembling...
5.
Lagal D, Barcena J, Requejo-Aguilar R, Padilla C, Leto T
Adv Redox Res
. 2023 Oct;
9.
PMID: 37900981
The NADPH oxidase 1 (NOX1) complex formed by proteins NOX1, p22phox, NOXO1, NOXA1, and RAC1 plays an important role in the generation of superoxide and other reactive oxygen species (ROS)...
6.
Lagal D, Lopez-Grueso M, Pedrajas J, Leto T, Barcena J, Requejo-Aguilar R, et al.
Antioxidants (Basel)
. 2023 Jun;
12(6).
PMID: 37371884
Peroxiredoxin 6 (PRDX6), the only mammalian 1-Cys member of the peroxiredoxin family, has peroxidase, phospholipase A2 (PLA2), and lysophosphatidylcholine (LPC) acyltransferase (LPCAT) activities. It has been associated with tumor progression...
7.
Boudreau H, Korzeniowska A, Leto T
Free Radic Biol Med
. 2023 Feb;
199:17-25.
PMID: 36804453
Previously, we showed wild-type (WT) and mutant (mt) forms of p53 differentially regulate ROS generation by NADPH oxidase-4 (NOX4). We found that WT-p53 suppresses TGF-β-induced NOX4, ROS production, and cell...
8.
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Mason H, Rai G, Kozyr A, De Jonge N, Gliniewicz E, Berg L, et al.
Redox Biol
. 2023 Jan;
60:102611.
PMID: 36709665
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction...
9.
Hsu A, Korzeniowska A, Aguilar C, Gu J, Karlins E, Oler A, et al.
JCI Insight
. 2022 Sep;
7(22).
PMID: 36166305
Disseminated coccidioidomycosis (DCM) is caused by Coccidioides, pathogenic fungi endemic to the southwestern United States and Mexico. Illness occurs in approximately 30% of those infected, less than 1% of whom...
10.
Donko A, Kuhns D, Cousin M, Smith M, Sacco K, Klee E, et al.
J Clin Immunol
. 2022 Mar;
42(5):986-999.
PMID: 35344128
Purpose: This is a functional characterization of a novel CYBA variant associated with normal DHR flow cytometry. Chronic granulomatous disease (CGD) is an inborn error of immunity characterized by recurrent...