Thomas L Leto
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Explore the profile of Thomas L Leto including associated specialties, affiliations and a list of published articles.
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68
Citations
2439
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Recent Articles
11.
Schnappauf O, Heale L, Dissanayake D, Tsai W, Gadina M, Leto T, et al.
Pediatr Rheumatol Online J
. 2021 Apr;
19(1):54.
PMID: 33892719
Background: Biallelic loss-of-function variants in NCF1 lead to reactive oxygen species deficiency and chronic granulomatous disease (CGD). Heterozygosity for the p.Arg90His variant in NCF1 has been associated with susceptibility to...
12.
Ma W, Boudreau H, Leto T
Antioxidants (Basel)
. 2021 Feb;
10(2).
PMID: 33557266
Previously, we have shown TGF-β-induced NOX4 expression is involved in the epithelial-to-mesenchymal transition (EMT), a process critical for cancer metastasis, and that wild-type (WT) and mutant (Mut) p53 have divergent...
13.
Stern H, Donko A, Shapiro T, Hsu A, Leto T, Holland S, et al.
J Clin Immunol
. 2020 Nov;
41(2):473-476.
PMID: 33188496
No abstract available.
14.
Boudreau H, Leto T
Methods Mol Biol
. 2019 Jun;
1982:473-485.
PMID: 31172490
There is mounting evidence indicating that reactive oxygen species (ROS) play a crucial role in cell migration and invasion. Our previous studies have demonstrated the NADPH oxidase (NOX) family of...
15.
Korzeniowska A, Donko A, Morand S, Leto T
Methods Mol Biol
. 2019 Jun;
1982:173-190.
PMID: 31172473
Biosynthesis of active human dual oxidases (DUOX1 and DUOX2) requires maturation factors, a.k.a. DUOX activator proteins (DUOXA1 and DUOXA2), that form covalent complexes with DUOX; both chains together represent the...
16.
Sharapova S, Haapaniemi E, Sakovich I, Kostyuchenko L, Donko A, Dulau-Florea A, et al.
Clin Immunol
. 2019 May;
205:1-5.
PMID: 31071452
Here we describe a 10-year-old girl with combined immunodeficiency presenting as recurring chest infections, lung disease and herpetic skin infections. The patient experienced two hematopoietic stem cell transplantations and despite...
17.
Hsu A, Donko A, Arrington M, Swamydas M, Fink D, Das A, et al.
Blood
. 2019 Feb;
133(18):1977-1988.
PMID: 30723080
Ras-related C3 botulinum toxin substrate 2 (RAC2), through interactions with reduced NAD phosphate oxidase component p67 , activates neutrophil superoxide production, whereas interactions with p21-activated kinase are necessary for fMLF-induced...
18.
Sugamata R, Donko A, Murakami Y, Boudreau H, Qi C, Kwon J, et al.
J Immunol
. 2018 Dec;
202(2):428-440.
PMID: 30559322
Engagement of the BCR with Ags triggers signaling pathways for commitment of B lymphocyte responses that can be regulated, in part, by reactive oxygen species. To investigate the functional relevance...
19.
Moody T, Lee L, Iordanskaia T, Ramos-Alvarez I, Moreno P, Boudreau H, et al.
Peptides
. 2018 Oct;
120:170017.
PMID: 30273693
Pituitary adenylate cyclase activating polypeptide (PACAP) is a growth factor for lung cancer cells. PACAP-27 or PACAP-38 binds with high affinity to non-small cell lung cancer (NSCLC) cells, causing elevated...
20.