Terrence R Burke Jr
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Explore the profile of Terrence R Burke Jr including associated specialties, affiliations and a list of published articles.
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157
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2530
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Recent Articles
21.
Miller S, Tsuji K, Abrams R, Burke Jr T, Schneider J
J Am Chem Soc
. 2020 Nov;
142(47):19950-19955.
PMID: 33175531
Here, we describe the use of peptide backbone -methylation as a new strategy to transform membrane-lytic peptides (MLPs) into cytocompatible intracellular delivery vehicles. The ability of lytic peptides to engage...
22.
Smith S, Zhao X, Oliveira Passos D, Lyumkis D, Burke Jr T, Hughes S
Antimicrob Agents Chemother
. 2020 Jul;
64(9).
PMID: 32601157
The currently recommended first-line therapy for HIV-1-infected patients is an integrase (IN) strand transfer inhibitor (INSTI), either dolutegravir (DTG) or bictegravir (BIC), in combination with two nucleoside reverse transcriptase inhibitors...
23.
Zhao X, Liu F, Burke Jr T
Molecules
. 2020 Jun;
25(12).
PMID: 32570752
Protein-protein interactions (PPIs) represent an extremely attractive class of potential new targets for therapeutic intervention; however, the shallow extended character of many PPIs can render developing inhibitors against them as...
24.
Qi J, Tsuji K, Hymel D, Burke Jr T, Hudecek M, Rader C, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(29):12178-12185.
PMID: 32329959
Although macromolecules on cell surfaces are predominantly targeted and drugged with antibodies, they harbor pockets that are only accessible to small molecules and constitutes a rich subset of binding sites...
25.
Oliveira Passos D, Li M, Jozwik I, Zhao X, Santos-Martins D, Yang R, et al.
Science
. 2020 Feb;
367(6479):810-814.
PMID: 32001521
The HIV intasome is a large nucleoprotein assembly that mediates the integration of a DNA copy of the viral genome into host chromatin. Intasomes are targeted by the latest generation...
26.
Hwang D, Tsuji K, Park H, Burke Jr T, Rader C
Bioconjug Chem
. 2019 Nov;
30(11):2889-2896.
PMID: 31675216
By exploiting a uniquely reactive lysine residue (Lys99) for site-specific attachment of small molecules, the humanized catalytic antibody h38C2 has been used as bioconjugation module in the assembly of chemically...
27.
Qi J, Hymel D, Nelson C, Burke Jr T, Rader C
Front Immunol
. 2019 Sep;
10:1994.
PMID: 31497024
T-cell engaging bispecific antibodies (biAbs) can mediate potent and specific tumor cell eradication in liquid cancers. Substantial effort has been invested in expanding this concept to solid cancers. To explore...
28.
Zhao X, Tsuji K, Hymel D, Burke Jr T
Molecules
. 2019 Apr;
24(8).
PMID: 31014020
Members of the polo-like kinase (Plk) family of serine/threonine protein kinases play crucial roles in cell cycle regulation and proliferation. Of the five Plks (Plk1-5), Plk1 is recognized as an...
29.
Hogan M, Bahta M, Tsuji K, Nguyen T, Cherry S, Lountos G, et al.
ACS Comb Sci
. 2019 Jan;
21(3):158-170.
PMID: 30629404
Chemical library screening approaches that focus exclusively on catalytic events may overlook unique effects of protein-protein interactions that can be exploited for development of specific inhibitors. Phosphotyrosyl (pTyr) residues embedded...
30.
Lountos G, Raran-Kurussi S, Zhao B, Dyas B, Burke Jr T, Ulrich R, et al.
Acta Crystallogr D Struct Biol
. 2018 Oct;
74(Pt 10):1015-1026.
PMID: 30289412
Here, new crystal structures are presented of the isolated membrane-proximal D1 and distal D2 domains of protein tyrosine phosphatase epsilon (PTPℇ), a protein tyrosine phosphatase that has been shown to...