Terrence R Burke Jr
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Explore the profile of Terrence R Burke Jr including associated specialties, affiliations and a list of published articles.
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157
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2530
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Recent Articles
11.
Mahajan P, Smith S, Hughes S, Zhao X, Burke Jr T
Molecules
. 2023 Feb;
28(3).
PMID: 36771093
An efficient one-pot synthetic method has been developed for the preparation of bicyclic carbamoyl pyridones from the known common intermediate methyl 5-((2,4-difluorobenzyl)carbamoyl)-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate (). The scalable protocol is facile and employs...
12.
Tsuji K, Hymel D, Ma B, Tamamura H, Nussinov R, Burke Jr T
RSC Chem Biol
. 2022 Sep;
3(9):1111-1120.
PMID: 36128509
The polo-like kinase 1 (Plk1) is an important mediator of cell cycle regulation and a recognized anti-cancer molecular target. In addition to its catalytic kinase domain (KD), Plk1 contains a...
13.
Zhao X, Wang W, Lountos G, Tropea J, Needle D, Pommier Y, et al.
Front Chem
. 2022 Sep;
10:910953.
PMID: 36051621
Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs stalled type I topoisomerase (TOP1)-DNA complexes by hydrolyzing the phosphodiester bond between the TOP1 Y723 residue and the 3'-phosphate of its DNA substrate. Although TDP1...
14.
Smith S, Ferris A, Zhao X, Pauly G, Schneider J, Burke Jr T, et al.
Viruses
. 2021 Dec;
13(12).
PMID: 34960770
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral compounds that prevent the insertion of a DNA copy of the viral genome into the host genome by targeting the...
15.
Barski M, Vanzo T, Zhao X, Smith S, Ballandras-Colas A, Cronin N, et al.
Nat Commun
. 2021 Oct;
12(1):5927.
PMID: 34611170
No abstract available.
16.
Barski M, Vanzo T, Zhao X, Smith S, Ballandras-Colas A, Cronin N, et al.
Nat Commun
. 2021 Aug;
12(1):4996.
PMID: 34404793
Between 10 and 20 million people worldwide are infected with the human T-cell lymphotropic virus type 1 (HTLV-1). Despite causing life-threatening pathologies there is no therapeutic regimen for this deltaretrovirus....
17.
Hymel D, Tsuji K, Grant R, Chingle R, Kunciw D, Yaffe M, et al.
Org Biomol Chem
. 2021 Aug;
19(36):7843-7854.
PMID: 34346472
Targeting protein - protein interactions (PPIs) has emerged as an important area of discovery for anticancer therapeutic development. In the case of phospho-dependent PPIs, such as the polo-like kinase 1...
18.
Zhao X, Kiselev E, Lountos G, Wang W, Tropea J, Needle D, et al.
Chem Sci
. 2021 Jun;
12(11):3876-3884.
PMID: 34163656
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a member of the phospholipase D family of enzymes, which catalyzes the removal of both 3'- and 5'-DNA phosphodiester adducts. Importantly, it is capable of...
19.
Smith S, Zhao X, Oliveira Passos D, Pye V, Cherepanov P, Lyumkis D, et al.
ACS Infect Dis
. 2021 Mar;
7(6):1469-1482.
PMID: 33686850
Integrase strand transfer inhibitors (INSTIs) block the integration step of the retroviral lifecycle and are first-line drugs used for the treatment of HIV-1/AIDS. INSTIs have a polycyclic core with heteroatom...
20.
Smith S, Zhao X, Oliveira Passos D, Lyumkis D, Burke Jr T, Hughes S
Viruses
. 2021 Feb;
13(2).
PMID: 33572956
Integrase strand transfer inhibitors (INSTIs) are currently recommended for the first line treatment of human immunodeficiency virus type one (HIV-1) infection. The first-generation INSTIs are effective but can select for...