Tatjana I Cornu
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Explore the profile of Tatjana I Cornu including associated specialties, affiliations and a list of published articles.
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34
Citations
953
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Recent Articles
21.
Mlambo T, Romito M, Cornu T, Mussolino C
Methods Mol Biol
. 2018 Mar;
1767:189-203.
PMID: 29524135
The development of tools which allow for the precise alterations of the epigenetic landscape in desired genomic locations presents exciting possibilities toward further understanding how gene expression is regulated and...
22.
Cornu T, Mussolino C, Cathomen T
Nat Med
. 2017 Apr;
23(4):415-423.
PMID: 28388605
Recent progress in developing programmable nucleases, such as zinc-finger nucleases, transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR)-Cas nucleases, have paved the way for gene...
23.
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases
Cornu T, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung J, et al.
Mol Ther
. 2017 Feb;
16(2):352-358.
PMID: 28178540
The engineering of proteins to manipulate cellular genomes has developed into a promising technology for biomedical research, including gene therapy. In particular, zinc-finger nucleases (ZFNs), which consist of a nonspecific...
24.
Cornu T, Mussolino C, Bloom K, Cathomen T
Adv Exp Med Biol
. 2015 Mar;
848:117-30.
PMID: 25757618
Acquired immunodeficiency syndrome (AIDS) is a life-threatening disorder caused by infection of individuals with the human immunodeficiency virus (HIV). Entry of HIV-1 into target cells depends on the presence of...
25.
Handel E, Gellhaus K, Khan K, Bednarski C, Cornu T, Muller-Lerch F, et al.
Hum Gene Ther
. 2011 Oct;
23(3):321-9.
PMID: 21980922
Zinc-finger nucleases (ZFNs) have become a valuable tool for targeted genome engineering. Based on the enzyme's ability to create a site-specific DNA double-strand break, ZFNs promote genome editing by activating...
26.
Sollu C, Pars K, Cornu T, Thibodeau-Beganny S, Maeder M, Joung J, et al.
Nucleic Acids Res
. 2010 Aug;
38(22):8269-76.
PMID: 20716517
Zinc-finger nucleases (ZFNs) have been successfully used for rational genome engineering in a variety of cell types and organisms. ZFNs consist of a non-specific FokI endonuclease domain and a specific...
27.
Cornu T, Cathomen T
Methods Mol Biol
. 2010 Aug;
649:237-45.
PMID: 20680838
The recent development of artificial zinc finger nucleases (ZFNs) for targeted genome editing has opened a broad range of possibilities in biotechnology and gene therapy. The ZFN technology allows a...
28.
Gellhaus K, Cornu T, Heilbronn R, Cathomen T
Hum Gene Ther
. 2009 Dec;
21(5):543-53.
PMID: 20021219
Recombinant vectors based on adeno-associated virus (rAAV) are promising tools to specifically alter complex genomes through homologous recombination (HR)-based gene targeting. In a therapeutic setting, an AAV donor vector will...
29.
Ramirez C, Foley J, Wright D, Muller-Lerch F, Rahman S, Cornu T, et al.
Nat Methods
. 2008 May;
5(5):374-5.
PMID: 18446154
No abstract available.
30.
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases
Cornu T, Thibodeau-Beganny S, Guhl E, Alwin S, Eichtinger M, Joung J, et al.
Mol Ther
. 2007 Nov;
16(2):352-8.
PMID: 18026168
The engineering of proteins to manipulate cellular genomes has developed into a promising technology for biomedical research, including gene therapy. In particular, zinc-finger nucleases (ZFNs), which consist of a nonspecific...