Tatjana I Cornu
Overview
Explore the profile of Tatjana I Cornu including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
953
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Recent Articles
11.
Konig S, Fliegauf M, Rhiel M, Grimbacher B, Cornu T, Cathomen T, et al.
Genes (Basel)
. 2022 Oct;
13(10).
PMID: 36292796
Dominant negative mutations in the gene account for autosomal dominant hyper-IgE syndrome (AD-HIES). Patients typically present high IgE serum levels, recurrent infections, and soft tissue abnormalities. While current therapies focus...
12.
Knipping F, Newby G, Eide C, McElroy A, Nielsen S, Smith K, et al.
Mol Ther
. 2021 Nov;
30(1):130-144.
PMID: 34737067
Disruption of CCR5 or CXCR4, the main human immunodeficiency virus type 1 (HIV-1) co-receptors, has been shown to protect primary human CD4 T cells from HIV-1 infection. Base editing can...
13.
Turchiano G, Andrieux G, Klermund J, Blattner G, Pennucci V, El Gaz M, et al.
Cell Stem Cell
. 2021 Feb;
28(6):1136-1147.e5.
PMID: 33626327
Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by...
14.
Alzubi J, Lock D, Rhiel M, Schmitz S, Wild S, Mussolino C, et al.
Mol Ther Methods Clin Dev
. 2021 Feb;
20:379-388.
PMID: 33575430
The potential of adoptive cell therapy can be extended when combined with genome editing. However, variation in the quality of the starting material and the different manufacturing steps are associated...
15.
Cornu T, Mussolino C, Muller M, Wehr C, Kern W, Cathomen T
Hum Gene Ther
. 2020 Dec;
32(1-2):52-65.
PMID: 33349126
Progress in antiretroviral therapy has considerably reduced mortality and notably improved the quality of life of individuals infected with HIV since the pandemic began some 40 years ago. However, drug...
16.
Romito M, Juillerat A, Kok Y, Hildenbeutel M, Rhiel M, Andrieux G, et al.
Biotechnol J
. 2020 Oct;
16(1):e2000023.
PMID: 33103367
Therapies to treat patients infected with human immunodeficiency virus (HIV) aim at preventing viral replication but fail to eliminate the virus. Although transplantation of allogeneic CCR5Δ32 homozygous stem cell grafts...
17.
Tarakanchikova Y, Alzubi J, Pennucci V, Follo M, Kochergin B, Muslimov A, et al.
Small
. 2019 Dec;
16(3):e1904880.
PMID: 31840408
Efficient delivery of genetic material to primary cells remains challenging. Here, efficient transfer of genetic material is presented using synthetic biodegradable nanocarriers, resembling extracellular vesicles in their biomechanical properties. This...
18.
Patsali P, Turchiano G, Papasavva P, Romito M, Loucari C, Stephanou C, et al.
Haematologica
. 2019 Apr;
104(11):e497-e501.
PMID: 31004018
No abstract available.
19.
Mlambo T, Romito M, Cornu T, Mussolino C
Methods Mol Biol
. 2018 May;
1767:E1.
PMID: 29748848
No abstract available.
20.
Mlambo T, Nitsch S, Hildenbeutel M, Romito M, Muller M, Bossen C, et al.
Nucleic Acids Res
. 2018 Mar;
46(9):4456-4468.
PMID: 29538770
Targeted modulation of gene expression represents a valuable approach to understand the mechanisms governing gene regulation. In a therapeutic context, it can be exploited to selectively modify the aberrant expression...