Tanja Holopainen
Overview
Explore the profile of Tanja Holopainen including associated specialties, affiliations and a list of published articles.
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25
Citations
1315
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0
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Recent Articles
1.
Nissinen T, Hentila J, Penna F, Lampinen A, Lautaoja J, Fachada V, et al.
J Cachexia Sarcopenia Muscle
. 2018 May;
9(3):514-529.
PMID: 29722201
Background: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. Methods:...
2.
Honkanen H, Izzi V, Petaisto T, Holopainen T, Harjunen V, Pihlajaniemi T, et al.
Neoplasia
. 2016 Jul;
18(7):436-46.
PMID: 27435926
Vascular endothelial growth factor D (VEGF-D) promotes the lymph node metastasis of cancer by inducing the growth of lymphatic vasculature, but its specific roles in tumorigenesis have not been elucidated....
3.
Holopainen T, Rasanen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(42):13063-8.
PMID: 26430242
Cardiac hypertrophy accompanies many forms of heart disease, including ischemic disease, hypertension, heart failure, and valvular disease, and it is a strong predictor of increased cardiovascular morbidity and mortality. Deletion...
4.
Turkki R, Linder N, Holopainen T, Wang Y, Grote A, Lundin M, et al.
J Clin Pathol
. 2015 May;
68(8):614-21.
PMID: 26021331
Aims: To build and evaluate an automated method for assessing tumour viability in histological tissue samples using texture features and supervised learning. Methods: H&E-stained sections (n=56) of human non-small cell...
5.
Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, et al.
Cancer Res
. 2015 Mar;
75(10):2083-94.
PMID: 25808867
Lymphatic invasion and accumulation of continuous collagen bundles around tumor cells are associated with poor melanoma prognosis, but the underlying mechanisms and molecular determinants have remained unclear. We show here...
6.
Wiener Z, Hogstrom J, Hyvonen V, Band A, Kallio P, Holopainen T, et al.
Duodecim
. 2015 Jan;
130(21):2208.
PMID: 25582015
No abstract available.
7.
Wiener Z, Hogstrom J, Hyvonen V, Band A, Kallio P, Holopainen T, et al.
Cell Rep
. 2014 Sep;
8(6):1943-1956.
PMID: 25242330
Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing...
8.
Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, et al.
Genes Dev
. 2014 Jul;
28(14):1592-603.
PMID: 25030698
Primitive lymphatic vessels are remodeled into functionally specialized initial and collecting lymphatics during development. Lymphatic endothelial cell (LEC) junctions in initial lymphatics transform from a zipper-like to a button-like pattern...
9.
Jeltsch M, Kumar Jha S, Tvorogov D, Anisimov A, Leppanen V, Holopainen T, et al.
Circulation
. 2014 Feb;
129(19):1962-71.
PMID: 24552833
Background: Hennekam lymphangiectasia-lymphedema syndrome (Online Mendelian Inheritance in Man 235510) is a rare autosomal recessive disease, which is associated with mutations in the CCBE1 gene. Because of the striking phenotypic...
10.
DAmico G, Korhonen E, Anisimov A, Zarkada G, Holopainen T, Hagerling R, et al.
J Clin Invest
. 2014 Jan;
124(2):824-34.
PMID: 24430181
The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we...