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Kari Alitalo

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Articles 396
Citations 29427
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Recent Articles
1.
Gucciardo F, Lebeau A, Pirson S, Buntinx F, Ivanova E, Blacher S, et al.
Circulation . 2025 Mar; PMID: 40035133
Background: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis. We investigated whether lymphedema could be attenuated by interfering with uPARAP (urokinase plasminogen activator...
2.
Kallio P, Bessone C, Seyednasrollah F, Brodkin J, Lassila M, Hogstrom J, et al.
Cancer Res . 2025 Jan; PMID: 39841093
Colorectal carcinoma (CRC) progression is associated with an increase in PROX1+ tumor cells, which exhibit features of CRC stem cells and contribute to metastasis. Here, we aimed to provide a...
3.
Lupu I, Grainger D, Kirschnick N, Weischer S, Zhao E, Martinez-Corral I, et al.
Nat Cardiovasc Res . 2025 Jan; 4(1):45-63. PMID: 39747454
During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes...
4.
Roos-Mattila M, Kallio P, Luck T, Polso M, Kumari R, Mikkonen P, et al.
Commun Biol . 2024 Oct; 7(1):1355. PMID: 39427059
Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor...
5.
Karaman S, Lehti S, Zhang C, Taskinen M, Kakela R, Mardinoglu A, et al.
FASEB J . 2024 Oct; 38(20):e70097. PMID: 39394863
Secondary lymphedema (LE) following breast cancer-related surgery is a life-long complication, which currently has no cure. LE induces significant regional adipose tissue deposition, requiring liposuction as a treatment. Here, we...
6.
Jeltsch M, Alitalo K
Nat Cardiovasc Res . 2024 Aug; 1(6):539-541. PMID: 39195860
No abstract available.
7.
Antila S, Chilov D, Nurmi H, Li Z, Nasi A, Gotkiewicz M, et al.
Nat Cardiovasc Res . 2024 Aug; 3:474-491. PMID: 39087029
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest in their...
8.
Keuters M, Antila S, Immonen R, Plotnikova L, Wojciechowski S, Lehtonen S, et al.
Transl Stroke Res . 2024 Jun; PMID: 38822994
Timely relief of edema and clearance of waste products, as well as promotion of anti-inflammatory immune responses, reduce ischemic stroke pathology, and attenuate harmful long-term effects post-stroke. The discovery of...
9.
Brouillard P, Murtomaki A, Leppanen V, Hyytiainen M, Mestre S, Potier L, et al.
J Clin Invest . 2024 May; 134(14). PMID: 38820174
Primary lymphedema (PL), characterized by tissue swelling, fat accumulation, and fibrosis, results from defects in lymphatic vessels or valves caused by mutations in genes involved in development, maturation, and function...
10.
Brakenhielm E, Sultan I, Alitalo K
Arterioscler Thromb Vasc Biol . 2024 Apr; 44(5):1016-1020. PMID: 38657034
No abstract available.