Tami Annable
Overview
Explore the profile of Tami Annable including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
272
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0
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Recent Articles
1.
Wu N, McDaniel K, Zhou T, Ramos-Lorenzo S, Wu C, Huang L, et al.
Am J Physiol Gastrointest Liver Physiol
. 2018 Jun;
315(3):G385-G398.
PMID: 29848019
microRNA-21 (miRNA) is one of the most abundant miRNAs in chronic liver injuries including alcoholic liver injury. Previous studies have demonstrated that miR-21 plays a role in inflammation in the...
2.
Wan Y, McDaniel K, Wu N, Ramos-Lorenzo S, Glaser T, Venter J, et al.
Am J Pathol
. 2017 Nov;
187(12):2788-2798.
PMID: 29128099
Alcoholic liver disease remains a major cause of liver-related morbidity and mortality, which ranges from alcoholic steatohepatitis to fibrosis/cirrhosis and hepatocellular carcinoma, and the related mechanisms are understood poorly. In...
3.
McDaniel K, Huang L, Sato K, Wu N, Annable T, Zhou T, et al.
J Biol Chem
. 2017 May;
292(27):11336-11347.
PMID: 28536261
The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the...
4.
Wan Y, Garner J, Wu N, Phillip L, Han Y, McDaniel K, et al.
J Cell Mol Med
. 2015 Dec;
20(2):195-203.
PMID: 26645107
Diabetes mellitus is one of the most severe endocrine metabolic disorders in the world that has serious medical consequences with substantial impacts on the quality of life. Type 2 diabetes...
5.
Annable T, Tomassian T, Jain S, Leibbrandt M, Cooke M, Deane J
Autoimmunity
. 2014 Dec;
48(1):29-39.
PMID: 25483245
Subunit vaccines are typically poorly immunogenic when administered alone, and require adjuvants for robust responses. Triggering TLRs to boost antigen-specific adaptive immunity is an attractive approach to increase the potency...
6.
Wash P, Hoffman T, Wiley B, Bonnefous C, Smith N, Sertic M, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(24):6482-5.
PMID: 18954984
In an effort to discover novel non-hydroxamic acid histone deacetylase (HDAC) inhibitors, a novel alpha-mercaptoketone was identified in a high-throughput screen. Lead optimization of the screening hit, led to a...
7.
Payne J, Bonnefous C, Hassig C, Symons K, Guo X, Nguyen P, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(23):6093-6.
PMID: 18954983
We report the identification of KD5170, a potent mercaptoketone-based Class I and II-histone deacetylase inhibitor that demonstrates broad spectrum cytotoxic activity against a range of human tumor-derived cell lines. KD5170...
8.
Hassig C, Symons K, Guo X, Nguyen P, Annable T, Wash P, et al.
Mol Cancer Ther
. 2008 May;
7(5):1054-65.
PMID: 18483295
Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of...
9.
Hari M, Loganzo F, Annable T, Tan X, Musto S, Morilla D, et al.
Mol Cancer Ther
. 2006 Mar;
5(2):270-8.
PMID: 16505100
Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well understood. We sought to characterize the resistance mechanisms that...
10.
Wissner A, Floyd M, Johnson B, Fraser H, Ingalls C, Nittoli T, et al.
J Med Chem
. 2005 Nov;
48(24):7560-81.
PMID: 16302797
A series of 2-(quinazolin-4-ylamino)-[1,4] benzoquinone derivatives that function as potent covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2 (VEGFR-2) has been prepared by ceric ammonium...