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Tami Annable

Explore the profile of Tami Annable including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 272
Followers 0
Related Specialties
Biochemistry
Chemistry
Oncology
Top 10 Co-Authors
Frank Loganzo
Sylvia Musto
Lee M Greenberger
Xingzhi Tan
Heather Francis
Tianhao Zhou
Gianfranco Alpini
Shannon Glaser
Kelly McDaniel
Nan Wu
Published In
Mol Cancer Ther
Bioorg Med Chem Lett
J Med Chem
Cancer Res
J Cell Mol Med
Affiliations
Soon will be listed here.
Recent Articles
11.
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability
Poruchynsky M, Kim J, Nogales E, Annable T, Loganzo F, Greenberger L, et al.
Biochemistry . 2004 Nov; 43(44):13944-54. PMID: 15518543
Hemiasterlins are sponge-derived tripeptides that inhibit cell growth by depolymerizing existing microtubules and inhibiting microtubule assembly. Since hemiasterlins are poor substrates for P-glycoprotein, they are attractive candidates for cancer therapy...
12.
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin
Loganzo F, Hari M, Annable T, Tan X, Morilla D, Musto S, et al.
Mol Cancer Ther . 2004 Oct; 3(10):1319-27. PMID: 15486199
HTI-286, a synthetic analogue of hemiasterlin, depolymerizes microtubules and is proposed to bind at the Vinca peptide site in tubulin. It has excellent in vivo antitumor activity in human xenograft...
13.
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment
Yamashita A, Norton E, Kaplan J, Niu C, Loganzo F, Hernandez R, et al.
Bioorg Med Chem Lett . 2004 Sep; 14(21):5317-22. PMID: 15454219
Analogs of hemiasterlin (1) and HTI-286 (2), which contain various aromatic rings in the A segment, were synthesized as potential inhibitors of tubulin polymerization. The structure-activity relationships related to stereo-...
14.
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286)
Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, et al.
J Med Chem . 2004 Sep; 47(19):4774-86. PMID: 15341492
Hemiasterlin, a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286, an analogue from an initial study of the hemiasterlins, is presently in clinical trials....
15.
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo
Sampath D, Discafani C, Loganzo F, Beyer C, Liu H, Tan X, et al.
Mol Cancer Ther . 2003 Oct; 2(9):873-84. PMID: 14555706
The taxanes, paclitaxel (PTX) and docetaxel (DTX), belong to a novel class of anticancer drugs that stabilize microtubules and lead to tumor cell death. While both agents are widely used...
16.
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
Loganzo F, Discafani C, Annable T, Beyer C, Musto S, Hari M, et al.
Cancer Res . 2003 Apr; 63(8):1838-45. PMID: 12702571
Hemiasterlin is a natural product derived from marine sponges that, like other structurally diverse peptide-like molecules, binds to the Vinca-peptide site in tubulin, disrupts normal microtubule dynamics, and, at stoichiometric...