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Tami Annable

Explore the profile of Tami Annable including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 272
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Recent Articles
11.
Poruchynsky M, Kim J, Nogales E, Annable T, Loganzo F, Greenberger L, et al.
Biochemistry . 2004 Nov; 43(44):13944-54. PMID: 15518543
Hemiasterlins are sponge-derived tripeptides that inhibit cell growth by depolymerizing existing microtubules and inhibiting microtubule assembly. Since hemiasterlins are poor substrates for P-glycoprotein, they are attractive candidates for cancer therapy...
12.
Loganzo F, Hari M, Annable T, Tan X, Morilla D, Musto S, et al.
Mol Cancer Ther . 2004 Oct; 3(10):1319-27. PMID: 15486199
HTI-286, a synthetic analogue of hemiasterlin, depolymerizes microtubules and is proposed to bind at the Vinca peptide site in tubulin. It has excellent in vivo antitumor activity in human xenograft...
13.
Yamashita A, Norton E, Kaplan J, Niu C, Loganzo F, Hernandez R, et al.
Bioorg Med Chem Lett . 2004 Sep; 14(21):5317-22. PMID: 15454219
Analogs of hemiasterlin (1) and HTI-286 (2), which contain various aromatic rings in the A segment, were synthesized as potential inhibitors of tubulin polymerization. The structure-activity relationships related to stereo-...
14.
Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, et al.
J Med Chem . 2004 Sep; 47(19):4774-86. PMID: 15341492
Hemiasterlin, a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286, an analogue from an initial study of the hemiasterlins, is presently in clinical trials....
15.
Sampath D, Discafani C, Loganzo F, Beyer C, Liu H, Tan X, et al.
Mol Cancer Ther . 2003 Oct; 2(9):873-84. PMID: 14555706
The taxanes, paclitaxel (PTX) and docetaxel (DTX), belong to a novel class of anticancer drugs that stabilize microtubules and lead to tumor cell death. While both agents are widely used...
16.
Loganzo F, Discafani C, Annable T, Beyer C, Musto S, Hari M, et al.
Cancer Res . 2003 Apr; 63(8):1838-45. PMID: 12702571
Hemiasterlin is a natural product derived from marine sponges that, like other structurally diverse peptide-like molecules, binds to the Vinca-peptide site in tubulin, disrupts normal microtubule dynamics, and, at stoichiometric...