Role of Stem Cells During Diabetic Liver Injury

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2015 Dec 10

PMID 26645107

Citations 12

Authors

Ying Wan

Jessica Garner

Nan Wu

Levine Phillip

Yuyan Han

Kelly McDaniel

Tami Annable

Tianhao Zhou

Heather Francis

Shannon Glaser

Qiaobing Huang

Gianfranco Alpini

Fanyin Meng

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus is one of the most severe endocrine metabolic disorders in the world that has serious medical consequences with substantial impacts on the quality of life. Type 2 diabetes is one of the main causes of diabetic liver diseases with the most common being non-alcoholic fatty liver disease. Several factors that may explain the mechanisms related to pathological and functional changes of diabetic liver injury include: insulin resistance, oxidative stress and endoplasmic reticulum stress. The realization that these factors are important in hepatocyte damage and lack of donor livers has led to studies concentrating on the role of stem cells (SCs) in the prevention and treatment of liver injury. Possible avenues that the application of SCs may improve liver injury include but are not limited to: the ability to differentiate into pancreatic β-cells (insulin producing cells), the contribution for hepatocyte regeneration, regulation of lipogenesis, glucogenesis and anti-inflammatory actions. Once further studies are performed to explore the underlying protective mechanisms of SCs and the advantages and disadvantages of its application, there will be a greater understand of the mechanism and therapeutic potential. In this review, we summarize the findings regarding the role of SCs in diabetic liver diseases.

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