Tamara Ratovitski
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Explore the profile of Tamara Ratovitski including associated specialties, affiliations and a list of published articles.
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23
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606
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Recent Articles
1.
Ratovitski T, Holland C, OMeally R, Shevelkin A, Shi T, Cole R, et al.
bioRxiv
. 2025 Jan;
PMID: 39763784
Huntington's Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD...
2.
Liu H, McCollum A, Krishnaprakash A, Ouyang Y, Shi T, Ratovitski T, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596381
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a single mutation in the huntingtin gene (HTT). Normal HTT has a CAG trinucleotide repeat at its N-terminal within...
3.
Ratovitski T, Kamath S, OMeally R, Gosala K, Holland C, Jiang M, et al.
Hum Mol Genet
. 2023 Aug;
32(20):3006-3025.
PMID: 37535888
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, coding for huntingtin protein (HTT). Mechanisms of HD cellular pathogenesis remain undefined...
4.
Ratovitski T, Jiang M, OMeally R, Rauniyar P, Chighladze E, Farago A, et al.
Hum Mol Genet
. 2021 Dec;
31(10):1651-1672.
PMID: 34888656
Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG expansion in the huntingtin gene (HTT). Post-translational modifications of huntingtin protein (HTT), such as phosphorylation, acetylation and ubiquitination,...
5.
Akimov S, Jiang M, Kedaigle A, Arbez N, Marque L, Eddings C, et al.
Hum Mol Genet
. 2021 Jul;
30(24):2469-2487.
PMID: 34296279
We have previously established induced pluripotent stem cell (iPSC) models of Huntington's disease (HD), demonstrating CAG-repeat-expansion-dependent cell biological changes and toxicity. However, the current differentiation protocols are cumbersome and time...
6.
Migazzi A, Scaramuzzino C, Anderson E, Tripathy D, Hernandez I, Grant R, et al.
Cell Rep
. 2021 Apr;
35(2):108980.
PMID: 33852844
The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is...
7.
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model
Xu X, Ng B, Sim B, Radulescu C, Yusof N, Goh W, et al.
Cell Death Dis
. 2020 Sep;
11(9):809.
PMID: 32978366
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by mutant huntingtin (mHTT). Phosphorylation at serine-421 (pS421) of mHTT has been shown to be neuroprotective in cellular and rodent models....
8.
Jiang M, Zhang X, Liu H, LeBron J, Alexandris A, Peng Q, et al.
Hum Mol Genet
. 2020 Apr;
29(8):1340-1352.
PMID: 32242231
Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but its function in the adult brain remains not well understood. In this study, we identify...
9.
Arbez N, Ratovitski T, Roby E, Chighladze E, Stewart J, Ren M, et al.
J Biol Chem
. 2017 Oct;
292(47):19238-19249.
PMID: 28972180
Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and...
10.
Ratovitski T, OMeally R, Jiang M, Chaerkady R, Chighladze E, Stewart J, et al.
J Proteome Res
. 2017 Jun;
16(8):2692-2708.
PMID: 28653853
Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified...