Robert N OMeally
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Explore the profile of Robert N OMeally including associated specialties, affiliations and a list of published articles.
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31
Citations
756
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Recent Articles
1.
Ratovitski T, Holland C, OMeally R, Shevelkin A, Shi T, Cole R, et al.
bioRxiv
. 2025 Jan;
PMID: 39763784
Huntington's Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD...
2.
Zhang G, Porter M, Awol A, Orsburn B, Canner S, Gray J, et al.
J Am Chem Soc
. 2024 Jun;
146(26):17801-17816.
PMID: 38887845
Gangliosides, sialic acid bearing glycosphingolipids, are components of the outer leaflet of plasma membranes of all vertebrate cells. They contribute to cell regulation by interacting with proteins in their own...
3.
Ratovitski T, Kamath S, OMeally R, Gosala K, Holland C, Jiang M, et al.
Hum Mol Genet
. 2023 Aug;
32(20):3006-3025.
PMID: 37535888
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, coding for huntingtin protein (HTT). Mechanisms of HD cellular pathogenesis remain undefined...
4.
Narayanan B, Zahra F, Reeves R, Aggarwal A, OMeally R, Henry R, et al.
Anal Biochem
. 2023 Jul;
678:115262.
PMID: 37507081
Thousands of mammalian intracellular proteins are dynamically modified by O-linked β-N-acetylglucosamine (O-GlcNAc). Global changes in O-GlcNAcylation have been associated with the development of cardiomyopathy, heart failure, hypertension, and neurodegenerative disease....
5.
Gutierrez-Hoffmann M, Fan J, OMeally R, Cole R, Florea L, Antonescu C, et al.
J Immunol
. 2023 Jul;
211(4):612-625.
PMID: 37405694
Dendritic cells bridge the innate and adaptive immune responses by serving as sensors of infection and as the primary APCs responsible for the initiation of the T cell response against...
6.
Smith J, OMeally R, Burke S, Ng D, Chen J, Kensler T, et al.
J Am Soc Mass Spectrom
. 2023 Mar;
34(4):595-607.
PMID: 36939690
Assessing personal exposure to environmental toxicants is a critical challenge for predicting disease risk. Previously, using human serum albumin (HSA)-based biomonitoring, we reported dosimetric relationships between adducts at HSA Cys...
7.
Vinson D, Stephens K, OMeally R, Bhat S, Dancy B, Cole R, et al.
Epigenetics Chromatin
. 2022 Nov;
15(1):36.
PMID: 36411491
Epigenetic modifications to histone proteins serve an important role in regulating permissive and repressive chromatin states, but despite the identification of many histone PTMs and their perceived role, the epigenetic...
8.
Ratovitski T, Jiang M, OMeally R, Rauniyar P, Chighladze E, Farago A, et al.
Hum Mol Genet
. 2021 Dec;
31(10):1651-1672.
PMID: 34888656
Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG expansion in the huntingtin gene (HTT). Post-translational modifications of huntingtin protein (HTT), such as phosphorylation, acetylation and ubiquitination,...
9.
Sell G, Xin W, Cook E, Zbinden M, Schaffer T, OMeally R, et al.
Sci Rep
. 2021 Oct;
11(1):19414.
PMID: 34593829
In humans, loss-of-function mutations in the UBE3A gene lead to the neurodevelopmental disorder Angelman syndrome (AS). AS patients have severe impairments in speech, learning and memory, and motor coordination, for...
10.
Smith J, OMeally R, Ng D, Chen J, Kensler T, Cole R, et al.
Chem Res Toxicol
. 2021 Apr;
34(4):1183-1196.
PMID: 33793228
Outdoor air pollution, a spatially and temporally complex mixture, is a human carcinogen. However, ambient measurements may not reflect subject-level exposures, personal monitors do not assess internal dose, and spot...