Ekaterine Chighladze
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Explore the profile of Ekaterine Chighladze including associated specialties, affiliations and a list of published articles.
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8
Citations
317
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Recent Articles
1.
Ratovitski T, Jiang M, OMeally R, Rauniyar P, Chighladze E, Farago A, et al.
Hum Mol Genet
. 2021 Dec;
31(10):1651-1672.
PMID: 34888656
Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG expansion in the huntingtin gene (HTT). Post-translational modifications of huntingtin protein (HTT), such as phosphorylation, acetylation and ubiquitination,...
2.
Arbez N, Ratovitski T, Roby E, Chighladze E, Stewart J, Ren M, et al.
J Biol Chem
. 2017 Oct;
292(47):19238-19249.
PMID: 28972180
Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs) control and regulate many protein functions and cellular pathways, and...
3.
Ratovitski T, OMeally R, Jiang M, Chaerkady R, Chighladze E, Stewart J, et al.
J Proteome Res
. 2017 Jun;
16(8):2692-2708.
PMID: 28653853
Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified...
4.
Ratovitski T, Arbez N, Stewart J, Chighladze E, Ross C
Cell Cycle
. 2015 May;
14(11):1716-29.
PMID: 25927346
Abnormal protein interactions of mutant huntingtin (Htt) triggered by polyglutamine expansion are thought to mediate Huntington's disease (HD) pathogenesis. Here, we explored a functional interaction of Htt with protein arginine...
5.
Ratovitski T, Chighladze E, Arbez N, Boronina T, Herbrich S, Cole R, et al.
Cell Cycle
. 2012 May;
11(10):2006-21.
PMID: 22580459
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) protein containing multiple HEAT...
6.
Ratovitski T, Chighladze E, Waldron E, Hirschhorn R, Ross C
J Biol Chem
. 2011 Feb;
286(14):12578-89.
PMID: 21310951
N-terminal proteolysis of huntingtin is thought to be an important mediator of HD pathogenesis. The formation of short N-terminal fragments of huntingtin (cp-1/cp-2, cp-A/cp-B) has been demonstrated in cells and...
7.
Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, DAmbola J, et al.
J Biol Chem
. 2009 Feb;
284(16):10855-67.
PMID: 19204007
Huntingtin proteolysis is implicated in Huntington disease pathogenesis, yet, the nature of huntingtin toxic fragments remains unclear. Huntingtin undergoes proteolysis by calpains and caspases within an N-terminal region between amino...
8.
Ratovitski T, Nakamura M, DAmbola J, Chighladze E, Liang Y, Wang W, et al.
Cell Cycle
. 2007 Dec;
6(23):2970-81.
PMID: 18156806
Proteolytic cleavage of mutant huntingtin may play a key role in the pathogenesis of Huntington's disease; however the steps in huntingtin proteolysis are not fully understood. Huntingtin was shown to...