Christopher A Ross
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Explore the profile of Christopher A Ross including associated specialties, affiliations and a list of published articles.
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237
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14970
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Recent Articles
1.
Ratovitski T, Holland C, OMeally R, Shevelkin A, Shi T, Cole R, et al.
bioRxiv
. 2025 Jan;
PMID: 39763784
Huntington's Disease (HD), a progressive neurodegenerative disorder with no disease-modifying therapies, is caused by a CAG repeat expansion in the HD gene encoding polyglutamine-expanded huntingtin (HTT) protein. Mechanisms of HD...
2.
Zhang L, Chen P, Chen T, Lin L, Ji X, Liu J, et al.
J Control Release
. 2024 Dec;
378:1139-1153.
PMID: 39722304
Rationale: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene play an important role in Parkinson's disease (PD) pathogenesis, and downregulation of LRRK2 has become a promising therapy for PD....
3.
Liu H, McCollum A, Krishnaprakash A, Ouyang Y, Shi T, Ratovitski T, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596381
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a single mutation in the huntingtin gene (HTT). Normal HTT has a CAG trinucleotide repeat at its N-terminal within...
4.
Hinkle J, Wildermuth E, Tong X, Ross C, Bang J
J Huntingtons Dis
. 2024 Sep;
13(3):315-320.
PMID: 39269851
Background: Anosognosia, or unawareness of symptoms, is common in Huntington's disease (HD), but the neuroanatomical basis of this is unknown. Objective: To identify neuroanatomical correlates of HD anosognosia using structural...
5.
Liu C, Younes L, Tong X, Hinkle J, Wang M, Phatak S, et al.
Brain Commun
. 2023 Sep;
5(5):fcad214.
PMID: 37744022
Huntington's disease is caused by a CAG repeat expansion in the Huntingtin gene (), coding for polyglutamine in the Huntingtin protein, with longer CAG repeats causing earlier age of onset....
6.
Ratovitski T, Kamath S, OMeally R, Gosala K, Holland C, Jiang M, et al.
Hum Mol Genet
. 2023 Aug;
32(20):3006-3025.
PMID: 37535888
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the HD gene, coding for huntingtin protein (HTT). Mechanisms of HD cellular pathogenesis remain undefined...
7.
Jin J, Arbez N, Sahn J, Lu Y, Linkens K, Hodges T, et al.
ACS Chem Neurosci
. 2022 Sep;
13(19):2852-2862.
PMID: 36108101
Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded CAG repeat in the () gene that encodes for an expanded polyglutamine (polyQ) repeat in exon-1 of the...
8.
Cordner Z, Khambadkone S, Zhu S, Bai J, Forti R, Goodman E, et al.
Complex Psychiatry
. 2022 Aug;
7(3-4):71-79.
PMID: 35928299
The locus has been repeatedly found to confer an increased risk for bipolar disorder. codes for Ankyrin-G (Ank-G), a scaffold protein concentrated at axon initial segments, nodes of Ranvier, and...
9.
Huang Y, Huang H, Zhou L, Li J, Chen X, Thomas J, et al.
Hum Mol Genet
. 2022 Jun;
31(22):3886-3896.
PMID: 35766879
The D620N mutation in vacuolar protein sorting protein 35 (VPS35) gene has been identified to be linked to late onset familial Parkinson disease (PD). However, the pathophysiological roles of VPS35-D620N...
10.
Tabrizi S, Schobel S, Gantman E, Mansbach A, Borowsky B, Konstantinova P, et al.
Lancet Neurol
. 2022 Jun;
21(7):632-644.
PMID: 35716693
The current research paradigm for Huntington's disease is based on participants with overt clinical phenotypes and does not address its pathophysiology nor the biomarker changes that can precede by decades...