Takashi Furusawa
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Explore the profile of Takashi Furusawa including associated specialties, affiliations and a list of published articles.
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32
Citations
928
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Recent Articles
11.
Kugler J, Postnikov Y, Furusawa T, Kimura S, Bustin M
Carcinogenesis
. 2017 Feb;
38(4):391-401.
PMID: 28186538
Thyroid cancer originates from genetic and epigenetic changes that alter gene expression and cellular signaling pathways. Here, we report that altered expression of the nucleosome-binding protein HMGN4 potentiates thyroid tumorigenesis....
12.
Zhang S, Zhu I, Deng T, Furusawa T, Rochman M, Vacchio M, et al.
Nucleic Acids Res
. 2016 Apr;
44(15):7144-58.
PMID: 27112571
The activation of naïve B lymphocyte involves rapid and major changes in chromatin organization and gene expression; however, the complete repertoire of nuclear factors affecting these genomic changes is not...
13.
Deng T, Zhu Z, Zhang S, Postnikov Y, Huang D, Horsch M, et al.
Genome Res
. 2015 Jul;
25(9):1295-308.
PMID: 26156321
DNase I hypersensitive sites (DHSs) are a hallmark of chromatin regions containing regulatory DNA such as enhancers and promoters; however, the factors affecting the establishment and maintenance of these sites...
14.
Furusawa T, Rochman M, Taher L, Dimitriadis E, Nagashima K, Anderson S, et al.
Nat Commun
. 2015 Jan;
6:6138.
PMID: 25609380
In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells,...
15.
Kimura Y, Kasuga S, Unno M, Furusawa T, Osoegawa S, Sasaki Y, et al.
Photosynth Res
. 2014 Dec;
124(1):19-29.
PMID: 25519852
A soluble cytochrome (Cyt) c' from thermophilic purple sulfur photosynthetic bacterium Thermochromatium (Tch.) tepidum exhibits marked thermal tolerance compared with that from the closely related mesophilic counterpart Allochromatium vinosum. Here,...
16.
Ciappio E, Krausz K, Rochman M, Furusawa T, Bonzo J, Tessarollo L, et al.
PLoS One
. 2014 Jan;
9(1):e84583.
PMID: 24392144
High mobility group nucleosome-binding protein 5 (HMGN5) is a chromatin architectural protein that binds specifically to nucleosomes and reduces the compaction of the chromatin fiber. The protein is present in...
17.
Postnikov Y, Furusawa T, Haines D, Factor V, Bustin M
Mol Cancer Res
. 2013 Dec;
12(1):82-90.
PMID: 24296759
Unlabelled: We report that HMGN1, a nucleosome-binding protein that affects chromatin structure and function, affects the growth of N-nitrosodiethylamine (DEN)-induced liver tumors. Following a single DEN injection at 2 weeks...
18.
Kugler J, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, et al.
J Biol Chem
. 2013 Apr;
288(23):16690-16703.
PMID: 23620591
The nuclei of most vertebrate cells contain members of the high mobility group N (HMGN) protein family, which bind specifically to nucleosome core particles and affect chromatin structure and function,...
19.
Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F, et al.
J Exp Med
. 2011 Dec;
209(1):157-71.
PMID: 22184635
Alarmins are endogenous mediators capable of promoting the recruitment and activation of antigen-presenting cells (APCs), including dendritic cells (DCs), that can potentially alert host defense against danger signals. However, the...
20.
Furusawa T, Cherukuri S
Biochim Biophys Acta
. 2010 Feb;
1799(1-2):69-73.
PMID: 20123069
High mobility group N (HMGN) proteins are the only nuclear proteins known to specifically recognize the generic structure of the 147-bp nucleosome core particle. Both in vitro and in vivo...