Developmental Function of HMGN Proteins

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2010 Feb 4

PMID 20123069

Citations 26

Authors

Takashi Furusawa

Srujana Cherukuri

Affiliations

Soon will be listed here.

Abstract

High mobility group N (HMGN) proteins are the only nuclear proteins known to specifically recognize the generic structure of the 147-bp nucleosome core particle. Both in vitro and in vivo experiments demonstrate that HMGN proteins are involved in epigenetic regulation by modulating chromatin structure and levels of posttranslational modifications of nucleosomal histones. Expression of HMGN proteins is developmentally regulated, and the loss or overexpression of these proteins can lead to developmental abnormalities. This review will focus on the role and on the possible molecular mechanism whereby HMGN proteins affect cellular differentiation and development.

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