Tad Eichler
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Explore the profile of Tad Eichler including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
235
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0
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Recent Articles
1.
Mobley H, Anderson M, Moricz B, Severin G, Holmes C, Ottosen E, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1012495.
PMID: 39178317
There is a critical gap in knowledge about how Gram-negative bacterial pathogens, using survival strategies developed for other niches, cause lethal bacteremia. Facultative anaerobic species of the Enterobacterales order are...
2.
Schwartz L, Simoni A, Yan P, Salamon K, Turkoglu A, Vasquez Martinez G, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2400666121.
PMID: 38976738
Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct. The collecting duct...
3.
Schwartz L, Salamon K, Simoni A, Eichler T, Jackson A, Murtha M, et al.
Cell Rep
. 2024 Mar;
43(4):114007.
PMID: 38517889
Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show...
4.
Schwartz L, Bochter M, Simoni A, Bender K, de Dios Ruiz Rosado J, Cotzomi-Ortega I, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2213363120.
PMID: 36652479
With the emergence of antibiotic-resistant bacteria, innovative approaches are needed for the treatment of urinary tract infections. Boosting antimicrobial peptide expression may provide an alternative to antibiotics. Here, we developed...
5.
Strieder-Barboza C, Flesher C, Geletka L, Eichler T, Akinleye O, Ky A, et al.
Adipocyte
. 2022 Dec;
11(1):665-675.
PMID: 36457256
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from...
6.
Pierce K, Eichler T, Mosquera Vasquez C, Schwaderer A, Simoni A, Creacy S, et al.
J Clin Invest
. 2021 Nov;
131(22).
PMID: 34779412
Ribonuclease 7 (RNase 7) is an antimicrobial peptide that prevents urinary tract infections (UTI); however, it is yet unknown how RNASE7 genetic variations affect its antimicrobial activity and its mitigation...
7.
Bender K, Schwartz L, Cohen A, Mosquera Vasquez C, Murtha M, Eichler T, et al.
Am J Physiol Renal Physiol
. 2021 Apr;
320(5):F972-F983.
PMID: 33818125
Antimicrobial peptides are essential host defense mechanisms that prevent urinary tract infections. Recent studies have demonstrated that peptides in the ribonuclease A superfamily have antimicrobial activity against uropathogens and protect...
8.
Eichler T, Bender K, Murtha M, Schwartz L, Metheny J, Solden L, et al.
J Am Soc Nephrol
. 2019 Jun;
30(8):1385-1397.
PMID: 31239387
Background: Evidence suggests that antimicrobial peptides, components of the innate immune response, protect the kidneys and bladder from bacterial challenge. We previously identified ribonuclease 7 (RNase 7) as a human...
9.
Murtha M, Eichler T, Bender K, Metheny J, Li B, Schwaderer A, et al.
J Clin Invest
. 2018 Nov;
128(12):5634-5646.
PMID: 30418175
People with diabetes mellitus have increased infection risk. With diabetes, urinary tract infection (UTI) is more common and has worse outcomes. Here, we investigate how diabetes and insulin resistance impact...
10.
Spencer J, Schwaderer A, Eichler T, Wang H, Kline J, Justice S, et al.
Kidney Int
. 2013 Oct;
85(5):1179-91.
PMID: 24107847
Recent studies stress the importance of antimicrobial peptides in protecting the urinary tract from infection. Previously, we have shown that ribonuclease 7 (RNase 7) is a potent antimicrobial peptide that...