John David Spencer
Overview
Explore the profile of John David Spencer including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
799
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0
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Recent Articles
1.
Cotzomi-Ortega I, Rosowski E, Wang X, Sanchez-Zamora Y, Lopez-Torres J, Sanchez-Orellana G, et al.
Mucosal Immunol
. 2024 Dec;
PMID: 39710133
The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of...
2.
Salamon K, Linn-Peirano S, Simoni A, Ruiz-Rosado J, Becknell B, John P, et al.
Diabetes Obes Metab
. 2024 Sep;
27(1):40-53.
PMID: 39344841
Aim: Sodium-glucose co-transporter-2 (SGLT2) inhibitors have revolutionized clinical medicine, but their association with urinary tract infection (UTI) risk remains debated. This study investigates the influence of dapagliflozin on UTI outcomes,...
3.
Schwartz L, Simoni A, Yan P, Salamon K, Turkoglu A, Vasquez Martinez G, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2400666121.
PMID: 38976738
Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct. The collecting duct...
4.
Cortado H, Kercsmar M, Li B, Vasquez-Martinez G, Gupta S, Ching C, et al.
J Innate Immun
. 2024 May;
16(1):283-294.
PMID: 38744252
Introduction: The ribonuclease (RNase) A superfamily encodes cationic antimicrobial proteins with potent microbicidal activity toward uropathogenic bacteria. Ribonuclease 6 (RNase6) is an evolutionarily conserved, leukocyte-derived antimicrobial peptide with potent microbicidal...
5.
Simoni A, Schwartz L, Junquera G, Ching C, Spencer J
Nat Rev Urol
. 2024 May;
21(12):707-722.
PMID: 38714857
Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes and prolong hospital stays. Consequently, new strategies are needed to prevent and control the spread of antibiotic resistance in...
6.
Marsh M, Junquera G, Stonebrook E, Spencer J, Watson J
Pediatr Rev
. 2024 Apr;
45(5):260-270.
PMID: 38689106
Despite the American Academy of Pediatrics guidelines for the evaluation, treatment, and management of urinary tract infections (UTIs), UTI diagnosis and management remains challenging for clinicians. Challenges with acute UTI...
7.
Spencer J, Connely T, Cooper J, Dowdall J
Undersea Hyperb Med
. 2024 Apr;
51(1):53-58.
PMID: 38615354
We present two cases of cricoid chondronecrosis treated with hyperbaric oxygen (HBO) therapy. Both patients presented with biphasic stridor and dyspnea several weeks after an intubation event. Tracheostomy was ultimately...
8.
Schwartz L, Salamon K, Simoni A, Eichler T, Jackson A, Murtha M, et al.
Cell Rep
. 2024 Mar;
43(4):114007.
PMID: 38517889
Urinary tract infections (UTIs) commonly afflict people with diabetes. To better understand the mechanisms that predispose diabetics to UTIs, we employ diabetic mouse models and altered insulin signaling to show...
9.
Mattoo T, Spencer J
Pediatr Nephrol
. 2024 Mar;
39(10):2833-2844.
PMID: 38483594
A prompt diagnosis of urinary tract infection (UTI) is necessary to minimize its symptoms and limit sequelae. The current UTI screening by urine test strip analysis and microscopic examination has...
10.
Ruiz-Rosado J, Cortado H, Kercsmar M, Li B, Ballash G, Cotzomi-Ortega I, et al.
J Innate Immun
. 2023 Nov;
15(1):865-875.
PMID: 37980892
Mounting evidence suggests that antimicrobial peptides and proteins (AMPs) belonging to the RNase A superfamily have a critical role in defending the bladder and kidney from bacterial infection. RNase 6...