T P Blackburn
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Explore the profile of T P Blackburn including associated specialties, affiliations and a list of published articles.
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58
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903
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Recent Articles
1.
Wood M, Reavill C, Trail B, Wilson A, Stean T, Kennett G, et al.
Neuropharmacology
. 2001 Aug;
41(2):186-99.
PMID: 11489455
SB-243213 (5-methyl-1-[[-2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline hydrochloride) is a new, selective 5-hydroxytryptamine (5-HT)2C receptor inverse agonist. SB-243213 has high affinity for the human 5-HT2C receptor (pK(i) 9.37) and greater than a 100-fold selectivity over...
2.
Blackburn T, Edge D, Williams A, Adams C
Neurosurgery
. 2000 Dec;
47(6):1261-85; discussion 1285-6.
PMID: 11126898
Man has sought to protect himself from physical injury resulting either from the vicissitudes of an arbitrary natural environment or from the calculated activity of his fellow creatures since at...
3.
Bromidge S, Davies S, Duckworth D, Forbes I, Jones G, Jones J, et al.
Bioorg Med Chem Lett
. 2000 Sep;
10(16):1867-70.
PMID: 10969987
Bisarylmethoxyethers have been identified with nanomolar 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 1, 2, 8, 12, 14 and 18 have potent oral activity...
4.
Bromidge S, Dabbs S, Davies S, Duckworth D, Forbes I, Jones G, et al.
Bioorg Med Chem Lett
. 2000 Sep;
10(16):1863-6.
PMID: 10969986
Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a...
5.
Branchek T, Blackburn T
Annu Rev Pharmacol Toxicol
. 2000 Jun;
40:319-34.
PMID: 10836139
5-ht6 receptors are the latest serotonin receptors to be identified by molecular cloning. Their high affinity for a wide range of drugs used in psychiatry, coupled with their intriguing distribution...
6.
Bromidge S, Dabbs S, DAVIES D, Davies S, Duckworth D, Forbes I, et al.
J Med Chem
. 2000 Mar;
43(6):1123-34.
PMID: 10737744
The evolution, synthesis, and biological activity of a novel series of 5-HT(2C) receptor inverse agonists are reported. Biarylcarbamoylindolines have been identified with excellent 5-HT(2C) affinity and selectivity over 5-HT(2A) receptors....
7.
Clemett D, Punhani T, Duxon M, Blackburn T, Fone K
Neuropharmacology
. 2000 Feb;
39(1):123-32.
PMID: 10665825
5-HT2C receptor mRNA has a widespread distribution in the human and rat CNS but the absence of a specific high affinity ligand has made autoradiographic localisation of the receptor difficult....
8.
Bromidge S, Dabbs S, DAVIES D, Davies S, Duckworth D, Forbes I, et al.
Bioorg Med Chem
. 2000 Feb;
7(12):2767-73.
PMID: 10658582
A model series of 5-HT2C antagonists have been prepared by rapid parallel synthesis. These N-substituted phenyl-N'-pyridin-3-yl ureas were found to have a range of 5-HT2C receptor affinities and selectivities over...
9.
Blackburn T, Doughty D, Plowman P
Br J Neurosurg
. 2000 Jan;
13(4):359-65.
PMID: 10616561
Six consecutively presenting patients with craniopharyngiomas, (F:M = 4.2; mean age: 35.2 years, range 17-58) histologically proven by one or more previous operations, and with recurrence of a wholly or...
10.
Reavill C, Kettle A, Holland V, Riley G, Blackburn T
Br J Pharmacol
. 1999 Apr;
126(3):572-4.
PMID: 10188965
Atypical neuroleptics produce fewer extrapyramidal side-effects (EPS) than typical neuroleptics. The pharmacological profile of atypical neuroleptics is that they have equivalent or higher antagonist affinity for 5-HT2 than for dopamine...