D N Middlemiss
Overview
Explore the profile of D N Middlemiss including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
2606
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Recent Articles
1.
Bush V, Middlemiss D, Marsden C, Fone K
J Neuroendocrinol
. 2003 Apr;
15(6):607-13.
PMID: 12716412
Many studies point to an involvement of deficits in the serotonergic nervous system and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis function with depression. Indeed early life stress, involving HPA axis...
2.
Roberts C, Watson J, Price G, Middlemiss D
CNS Drug Rev
. 2002 Feb;
7(4):433-44.
PMID: 11830759
5-HT1B autoreceptors are involved in the control of extracellular 5-HT levels from both the terminal and cell body regions of serotonergic neurons. In this manuscript we review the pharmacological and...
3.
Thomas D, Atkinson P, Hastie P, Roberts J, Middlemiss D, Price G
Neuropharmacology
. 2001 Dec;
42(1):74-81.
PMID: 11750917
The selective 5-HT7 receptor antagonist radioligand, [3H]-SB-269970, has been reported to radiolabel the human cloned 5-HT7(a) receptor and 5-HT7 receptors in guinea pig cortex (thomas et al, 2000). Saturation analysis...
4.
Roberts C, Price G, Middlemiss D
Brain Res Bull
. 2001 Dec;
56(5):463-9.
PMID: 11750791
The existence of multiple 5-HT autoreceptors in the central nervous system is now firmly established and they have been pharmacologically identified as belonging to the 5-HT(1A), 5-HT(1B), and 5-HT(1D) receptor...
5.
Ralevic V, Kendall D, Jerman J, Middlemiss D, Smart D
Eur J Pharmacol
. 2001 Oct;
424(3):211-9.
PMID: 11672565
The effects of three structurally related cannabinoids on human and rat recombinant vanilloid VR1 receptors expressed in human embryonic kidney (HEK293) cells and at endogenous vanilloid receptors in the rat...
6.
Wood M, Reavill C, Trail B, Wilson A, Stean T, Kennett G, et al.
Neuropharmacology
. 2001 Aug;
41(2):186-99.
PMID: 11489455
SB-243213 (5-methyl-1-[[-2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline hydrochloride) is a new, selective 5-hydroxytryptamine (5-HT)2C receptor inverse agonist. SB-243213 has high affinity for the human 5-HT2C receptor (pK(i) 9.37) and greater than a 100-fold selectivity over...
7.
Ralevic V, Kendall D, Jerman J, Davis J, Middlemiss D, Smart D
Auton Neurosci
. 2001 Jul;
88(1-2):36-44.
PMID: 11474544
The effect of low pH on capsaicin-sensitive sensory neurotransmission in the rat isolated mesenteric arterial bed and at recombinant (rVR1) vanilloid receptors was investigated. Mesenteric sensory neurogenic vasorelaxation elicited by...
8.
Watson J, Roberts C, Scott C, Kendall I, Collin L, Day N, et al.
Br J Pharmacol
. 2001 Jul;
133(6):797-806.
PMID: 11454652
A novel compound, SB-272183 (5-Chloro-2, 3-dihydro-6-[4-methylpiperazin-1-yl]-1[4-pyridin-4-yl]napth-1-ylaminocarbonyl]-1H-indole), has been shown to have high affinity for human 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptors with pK(i) values of 8.0, 8.1 and 8.7 respectively and...
9.
Medhurst A, Lezoualch F, Fischmeister R, Middlemiss D, Sanger G
Brain Res Mol Brain Res
. 2001 Jun;
90(2):125-34.
PMID: 11406291
5-HT4 receptors mediate several physiological effects of 5-HT, particularly in the central nervous system (CNS), heart and gut. Recently, several C-terminal splice variants of the human 5-HT4 (h5-HT4) receptor have...
10.
Roberts C, Allen L, Langmead C, Hagan J, Middlemiss D, Price G
Br J Pharmacol
. 2001 Mar;
132(7):1574-80.
PMID: 11264252
1. The presence of 5-HT(7) receptor mRNA and protein in 5-HT neurons suggests that this receptor may act as a 5-HT autoreceptor. In this study, the effect of the 5-HT(7)...