T A Stewart
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Explore the profile of T A Stewart including associated specialties, affiliations and a list of published articles.
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69
Citations
4620
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Recent Articles
21.
Maddux B, Sbraccia P, Kumakura S, Sasson S, Youngren J, Fisher A, et al.
Nature
. 1995 Feb;
373(6513):448-51.
PMID: 7830796
Most patients with non-insulin-dependent diabetes mellitus are resistant to both endogenous and exogenous insulin. Insulin resistance precedes the onset of this disease, suggesting that it may be an initial abnormality....
22.
Huang X, Hultgren B, Dybdal N, Stewart T
Immunity
. 1994 Sep;
1(6):469-78.
PMID: 7895158
The mechanism(s) leading to beta cell dysfunction in type I diabetes has not been defined. We have investigated whether islet expression of IFN alpha could be a cause of the...
23.
Hollingshead P, Warburton C, Dowd M, Dalton D, Gillett N, Stewart T
Genes Dev
. 1993 Dec;
7(12B):2609-17.
PMID: 8276243
IGF-I is a pleiotropic hormone reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems. In contrast to IGF-II, IGF-I is expressed at low levels...
24.
Cooper A, Dalton D, Stewart T, Griffin J, Russell D, Orme I
J Exp Med
. 1993 Dec;
178(6):2243-7.
PMID: 8245795
The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by T lymphocytes that secrete cytokines. These molecules then mediate a variety of roles, including the activation of...
25.
Flynn J, Chan J, Triebold K, Dalton D, Stewart T, Bloom B
J Exp Med
. 1993 Dec;
178(6):2249-54.
PMID: 7504064
Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate...
26.
Graham M, Dalton D, Giltinan D, Braciale V, Stewart T, Braciale T
J Exp Med
. 1993 Nov;
178(5):1725-32.
PMID: 8228818
Interferon gamma (IFN-gamma) is a pleiotropic cytokine secreted by T lymphocytes and natural killer (NK) cells and has been noted to be a first line of host defense in the...
27.
Stewart T, Hultgren B, Huang X, Hully J, MacLachlan N
Science
. 1993 Jun;
260(5116):1942-6.
PMID: 8100367
Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic beta cells, and the immune system in a genetically susceptible...
28.
Stewart T
Trends Endocrinol Metab
. 1993 May;
4(4):136-41.
PMID: 18407148
Although the primary etiology of some endocrine diseases is obvious, for many of them the initiating abnormality is not known. Usually this uncertainty is due to a slow development of...
29.
Dalton D, Keshav S, Figari I, Bradley A, Stewart T
Science
. 1993 Mar;
259(5102):1739-42.
PMID: 8456300
Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a targeted disruption of the IFN-gamma gene were generated. These mice developed normally...
30.
Martin L, Lucas C, Reynolds C, Stewart T
J Immunol
. 1993 Feb;
150(4):1234-43.
PMID: 8432978
Patients with type I diabetes lose immunologic tolerance to beta cell Ag and produce anti-self (beta cell) antibodies. We have examined mechanisms by which this self tolerance is lost using...