Sylvie Peraldi-Roux
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Explore the profile of Sylvie Peraldi-Roux including associated specialties, affiliations and a list of published articles.
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26
Citations
222
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Recent Articles
1.
Gautheron G, Peraldi-Roux S, Vaille J, Belhadj S, Patyra A, Bayle M, et al.
Br J Pharmacol
. 2024 Sep;
182(1):52-68.
PMID: 39327688
Background And Purpose: The pharmacology of flavonoids on β-cell function is largely undefined especially in the context of defective secretion of insulin. We sought to identify flavonoids that increased the...
2.
Peraldi-Roux S, Bayle M, MKadmi C, Damian M, Vaille J, Fernandez G, et al.
Biochem Pharmacol
. 2022 Jun;
202:115114.
PMID: 35659880
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor that regulates essential physiological functions. In particular, activation of GHSR in response to its endogenous agonist ghrelin promotes food...
3.
Laget J, Vigor C, Nouvel A, Rocher A, Leroy J, Jeanson L, et al.
Free Radic Biol Med
. 2022 Mar;
182:160-170.
PMID: 35227851
During early stages of type 2 diabetes, named prediabetes, pancreatic β-cells compensate for insulin resistance through increased insulin secretion in order to maintain normoglycemia. Obesity leads to the development of...
4.
Bayle M, Peraldi-Roux S, Gautheron G, Cros G, Oiry C, Neasta J
Fundam Clin Pharmacol
. 2021 Aug;
36(2):375-377.
PMID: 34449915
The hormone ghrelin is the endogenous agonist of the G protein-coupled receptor (GPCR) termed growth hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose-stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver-Expressed...
5.
Ben Haj Salah K, Maingot M, Blayo A, MKadmi C, Damian M, Mary S, et al.
J Med Chem
. 2020 Sep;
63(19):10796-10815.
PMID: 32882134
GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding, and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive activity...
6.
MKadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, et al.
J Med Chem
. 2018 Dec;
62(2):965-973.
PMID: 30543423
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. Liver-expressed antimicrobial peptide 2 (LEAP2)...
7.
Rebuffat S, Sidot E, Guzman C, Azay-Milhau J, Jover B, Lajoix A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Jul;
1864(10):3378-3387.
PMID: 30048752
Inflammatory factors produced and secreted by adipose tissue, in particular peri-pancreatic adipose tissue (P-WAT), may influence pancreatic β-cell dysfunction. Using the ZDF Rat model of diabetes, we show the presence...
8.
Chentouf M, Guzman C, Hamze M, Gross R, Lajoix A, Peraldi-Roux S
PLoS One
. 2014 Jul;
9(7):e102889.
PMID: 25068701
We recently reported that pancreatic islets from pre-diabetic rats undergo an inflammatory process in which IL-1β takes part and controls β-cell function. In the present study, using the INS-1 rat...
9.
Kammoun-Krichen M, Bougacha-Elleuch N, Mnif M, Bougacha F, Charffedine I, Rebuffat S, et al.
Eur Cytokine Netw
. 2012 Sep;
23(3):101-6.
PMID: 22995155
Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis. The purpose of the present study was to examine the...
10.
Leconet W, Petit P, Peraldi-Roux S, Bresson D
Mol Ther
. 2012 Sep;
20(12):2315-25.
PMID: 22990670
The development of small interfering RNA (siRNA) for the treatment of human disorders has been often hampered by their low transfection efficiency in vivo. In order to overcome this major...