Jeremie Neasta
Overview
Explore the profile of Jeremie Neasta including associated specialties, affiliations and a list of published articles.
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21
Citations
505
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Recent Articles
1.
Gautheron G, Peraldi-Roux S, Vaille J, Belhadj S, Patyra A, Bayle M, et al.
Br J Pharmacol
. 2024 Sep;
182(1):52-68.
PMID: 39327688
Background And Purpose: The pharmacology of flavonoids on β-cell function is largely undefined especially in the context of defective secretion of insulin. We sought to identify flavonoids that increased the...
2.
Patyra A, Vaille J, Omhmmed S, Dudek M, Neasta J, Kiss A, et al.
J Ethnopharmacol
. 2024 Apr;
329:118133.
PMID: 38580187
Ethnopharmacological Relevance: Angelica roots are a significant source of traditional medicines for various cultures around the northern hemisphere, from indigenous communities in North America to Japan. Among its many applications,...
3.
Peraldi-Roux S, Bayle M, MKadmi C, Damian M, Vaille J, Fernandez G, et al.
Biochem Pharmacol
. 2022 Jun;
202:115114.
PMID: 35659880
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor that regulates essential physiological functions. In particular, activation of GHSR in response to its endogenous agonist ghrelin promotes food...
4.
Bayle M, Peraldi-Roux S, Gautheron G, Cros G, Oiry C, Neasta J
Fundam Clin Pharmacol
. 2021 Aug;
36(2):375-377.
PMID: 34449915
The hormone ghrelin is the endogenous agonist of the G protein-coupled receptor (GPCR) termed growth hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose-stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver-Expressed...
5.
Ben Haj Salah K, Maingot M, Blayo A, MKadmi C, Damian M, Mary S, et al.
J Med Chem
. 2020 Sep;
63(19):10796-10815.
PMID: 32882134
GHSR controls, among others, growth hormone and insulin secretion, adiposity, feeding, and glucose metabolism. Therefore, an inverse agonist ligand capable of selectively targeting GHSR and reducing its high constitutive activity...
6.
Toubal S, Oiry C, Bayle M, Cros G, Neasta J
Fundam Clin Pharmacol
. 2020 Feb;
34(5):571-580.
PMID: 32083757
Polyphenols exert pharmacological actions through protein-mediated mechanisms and by modulating intracellular signalling pathways. We recently showed that a gut-microbial metabolite of ellagic acid named urolithin C is a glucose-dependent activator...
7.
Neasta J, Darcq E, Jeanblanc J, Carnicella S, Ben Hamida S
Neurotherapeutics
. 2020 Jan;
17(1):17-42.
PMID: 31919661
G protein-coupled receptors (GPCRs) constitute the largest class of cell surface signaling receptors and regulate major neurobiological processes. Accordingly, GPCRs represent primary targets for the treatment of brain disorders. Several...
8.
Bayle M, Neasta J, DallAsta M, Gautheron G, Virsolvy A, Quignard J, et al.
Br J Pharmacol
. 2019 Aug;
176(20):4065-4078.
PMID: 31378934
Background And Purpose: The pharmacology of polyphenol metabolites on beta-cell function is largely undetermined. We sought to identify polyphenol metabolites that enhance the insulin-secreting function of beta-cells and to explore...
9.
MKadmi C, Cabral A, Barrile F, Giribaldi J, Cantel S, Damian M, et al.
J Med Chem
. 2018 Dec;
62(2):965-973.
PMID: 30543423
The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. Liver-expressed antimicrobial peptide 2 (LEAP2)...
10.
Neasta J, Fiorenza A, He D, Phamluong K, Kiely P, Ron D
PLoS One
. 2016 Aug;
11(8):e0160948.
PMID: 27505161
RACK1 is a scaffolding protein that contributes to the specificity and propagation of several signaling cascades including the cAMP pathway. As such, RACK1 participates in numerous cellular functions ranging from...