Surendra K Shukla
Overview
Explore the profile of Surendra K Shukla including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
37
Citations
1183
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Mullen N, Shukla S, Thakur R, Kollala S, Wang D, Chaika N, et al.
Elife
. 2024 Jul;
12.
PMID: 38973593
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an...
2.
Sharma H, Mondal S, Urquiza U, Esparza C, Bartlett S, Santa-Pinter L, et al.
Eur J Med Chem
. 2024 Jun;
275():116598.
PMID: 38925013
Lactate dehydrogenase-A (LDHA) is the major isoform of lactate dehydrogenases (LDH) that is overexpressed and linked to poor survival in pancreatic ductal adenocarcinoma (PDAC). Despite some progress, current LDH inhibitors...
3.
Murthy D, Attri K, Shukla S, Thakur R, Chaika N, He C, et al.
Nat Cell Biol
. 2024 Apr;
26(5):840.
PMID: 38641662
No abstract available.
4.
Murthy D, Attri K, Suresh V, Rajacharya G, Valenzuela C, Thakur R, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(14):e2315509121.
PMID: 38547055
Dysregulation of polyamine metabolism has been implicated in cancer initiation and progression; however, the mechanism of polyamine dysregulation in cancer is not fully understood. In this study, we investigated the...
5.
Murthy D, Attri K, Shukla S, Thakur R, Chaika N, He C, et al.
Nat Cell Biol
. 2024 Mar;
26(4):613-627.
PMID: 38429478
The ability of tumour cells to thrive in harsh microenvironments depends on the utilization of nutrients available in the milieu. Here we show that pancreatic cancer-associated fibroblasts (CAFs) regulate tumour...
6.
He C, Wang D, Shukla S, Hu T, Thakur R, Fu X, et al.
Cancer Discov
. 2023 Nov;
14(1):176-193.
PMID: 37931287
Significance: The nutrient competition among the different tumor microenvironment components drives tumor growth, immune tolerance, and therapeutic resistance. PDAC cells demand a high amount of VB6, thus competitively causing NK-cell...
7.
Mullen N, Shukla S, Thakur R, Kollala S, Wang D, Chaika N, et al.
bioRxiv
. 2023 Apr;
PMID: 37066260
Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an...
8.
Mullen N, Thakur R, Shukla S, Chaika N, Kollala S, Wang D, et al.
Cancer Lett
. 2022 Nov;
552:215981.
PMID: 36341997
Inhibitors of dihydroorotate dehydrogenase (DHODH), a key enzyme for de novo synthesis of pyrimidine nucleotides, have failed in clinical trials for various cancers despite robust efficacy in preclinical animal models....
9.
Mohapatra B, Mirza S, Bele A, Gurumurthy C, Raza M, Saleem I, et al.
Mol Cancer Res
. 2022 Jun;
20(9):1391-1404.
PMID: 35675041
Implications: We demonstrate ECD overexpression in the mammary gland of mice led to the development of a tumor progression model through upregulation of c-MYC signaling and glucose metabolism.
10.
Xu P, You M, Yu S, Luan Y, Eldani M, Caffrey T, et al.
Sci Rep
. 2022 Feb;
12(1):1659.
PMID: 35102236
Pancreatic ductal adenocarcinoma (PDAC) patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. Activin A levels were...