Sujatha Jagannathan
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Explore the profile of Sujatha Jagannathan including associated specialties, affiliations and a list of published articles.
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27
Citations
593
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Recent Articles
11.
Jagannathan S, de Greef J, Hayward L, Yokomori K, Gabellini D, Mul K, et al.
Skelet Muscle
. 2022 Jan;
12(1):1.
PMID: 35039091
Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/early adulthood [1]....
12.
Child J, Chen Q, Reid D, Jagannathan S, Nicchitta C
RNA
. 2021 Jul;
27(10):1241-1256.
PMID: 34244458
Stress granules (SGs) are membraneless organelles composed of mRNAs and RNA binding proteins which undergo assembly in response to stress-induced inactivation of translation initiation. In general, SG recruitment is limited...
13.
Jagannathan S, Ramachandran S, Rissland O
Cell
. 2019 Aug;
178(4):774-776.
PMID: 31398334
In this issue of Cell, Cassidy et al. (2019) show that, in Drosophila melanogaster, developmental abnormalities resulting from loss of repressors such as microRNAs can be suppressed by slow metabolism....
14.
Dyle M, Kolakada D, Cortazar M, Jagannathan S
Wiley Interdiscip Rev RNA
. 2019 Jul;
11(1):e1560.
PMID: 31359616
Nonsense-mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control process that serves both as a mechanism to eliminate aberrant transcripts carrying premature stop codons, and to regulate expression...
15.
Jagannathan S, Ogata Y, Gafken P, Tapscott S, Bradley R
Elife
. 2019 Jan;
8.
PMID: 30644821
DUX4 is a transcription factor whose misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). DUX4's transcriptional activity has been extensively characterized, but the DUX4-induced proteome remains undescribed. Here, we...
16.
Campbell A, Shadle S, Jagannathan S, Lim J, Resnick R, Tawil R, et al.
Elife
. 2018 Mar;
7.
PMID: 29533181
The DUX4 transcription factor is encoded by a retrogene embedded in each unit of the D4Z4 macrosatellite repeat. DUX4 is normally expressed in the cleavage-stage embryo, whereas chromatin repression prevents...
17.
Jagannathan S, Bradley R
Genes Dev
. 2017 Jul;
31(11):1067-1068.
PMID: 28717044
Thomas and colleagues (pp. 1122-1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these...
18.
Feng Q, Jagannathan S, Bradley R
Mol Cell
. 2017 Jul;
67(2):239-251.e6.
PMID: 28669802
UPF1 is an RNA helicase that orchestrates nonsense-mediated decay and other RNA surveillance pathways. While UPF1 is best known for its basal cytoprotective role in degrading aberrant RNAs, UPF1 also...
19.
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al.
PLoS Genet
. 2017 Mar;
13(3):e1006658.
PMID: 28273136
Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of DUX4 in skeletal muscle cells. DUX4 is a transcription factor that activates genes normally associated with stem cell biology and its...
20.
Jagannathan S, Shadle S, Resnick R, Snider L, Tawil R, van der Maarel S, et al.
Hum Mol Genet
. 2017 Feb;
25(20):4419-4431.
PMID: 28171552
Facioscapulohumeral dystrophy (FSHD) is caused by the mis-expression of the double-homeodomain transcription factor DUX4 in skeletal muscle cells. Many different cell culture models have been developed to study the pathophysiology...