Robert K Bradley
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Explore the profile of Robert K Bradley including associated specialties, affiliations and a list of published articles.
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74
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7540
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Recent Articles
1.
Krishnamoorthy G, Glover A, Untch B, Sigcha-Coello N, Xu B, Vukel D, et al.
J Exp Med
. 2025 Feb;
222(5).
PMID: 39992626
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function RBM10 mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by RBM10 loss showed pro-migratory and RHO/RAC...
2.
Najjar R, Wang X, Pineda J, Alessi H, Bays A, Bradley R, et al.
ACR Open Rheumatol
. 2025 Jan;
7(1):e11770.
PMID: 39800670
Objective: To test whether messenger RNA (mRNA) splicing is altered in neutrophils from patients with systemic lupus erythematosus (SLE) and can produce neoantigens. Methods: RNA sequencing of neutrophils from patients...
3.
Gabel A, Belleville A, Thomas J, Pineda J, Bradley R
Genome Biol
. 2024 Oct;
25(1):255.
PMID: 39375704
Background: Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood. Results: We describe an...
4.
Belleville A, Thomas J, Tonnies J, Gabel A, Borrero Rossi A, Singh P, et al.
PLoS Genet
. 2024 Aug;
20(8):e1011363.
PMID: 39150991
Many of the most highly conserved elements in the human genome are "poison exons," alternatively spliced exons that contain premature termination codons and permit post-transcriptional regulation of mRNA abundance through...
5.
Krishnamoorthy G, Glover A, Untch B, Sigcha-Coello N, Xu B, Vukel D, et al.
bioRxiv
. 2024 Jul;
PMID: 39026820
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by RBM10 loss showed pro-migratory and RHO/RAC signaling...
6.
Sarchi M, Clough C, Crosse E, Kim J, Baquero Galvis L, Aydinyan N, et al.
Blood Cancer Discov
. 2024 Jun;
5(5):353-370.
PMID: 38856693
Splicing factor SF3B1 mutations are frequent somatic lesions in myeloid neoplasms that transform hematopoietic stem cells (HSCs) by inducing mis-splicing of target genes. However, the molecular and functional consequences of...
7.
Pineda J, Bradley R
Elife
. 2024 Jun;
12.
PMID: 38829686
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen...
8.
Benbarche S, Pineda J, Galvis L, Biswas J, Liu B, Wang E, et al.
Mol Cell
. 2024 Apr;
84(10):1886-1903.e10.
PMID: 38688280
Mutations in the RNA splicing factor gene SF3B1 are common across hematologic and solid cancers and result in widespread alterations in splicing, yet there is currently no therapeutic means to...
9.
Gabel A, Belleville A, Thomas J, McKellar S, Nicholas T, Banjo T, et al.
Nat Commun
. 2024 Feb;
15(1):959.
PMID: 38302465
Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because...
10.
Pineda J, Bradley R
bioRxiv
. 2023 Jul;
PMID: 37502871
Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. The embryonic transcription factor DUX4 was recently characterized as a suppressor of interferon-γ signaling and antigen...