Subathdrage D M Sumanadasa
Overview
Explore the profile of Subathdrage D M Sumanadasa including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
159
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Recent Articles
1.
Engel J, Jones A, Avery V, Sumanadasa S, Ng S, Fairlie D, et al.
Int J Parasitol Drugs Drug Resist
. 2016 Sep;
6(3):287.
PMID: 27682348
No abstract available.
2.
Skinner-Adams T, Sumanadasa S, Fisher G, Davis R, Doolan D, Andrews K
Drug Discov Today
. 2016 Jan;
21(5):725-39.
PMID: 26784142
The treatment of major human parasitic infections is dependent on drugs that are plagued by issues of drug resistance. New chemotherapeutics with novel mechanisms of action (MOA) are desperately needed...
3.
Engel J, Jones A, Avery V, Sumanadasa S, Ng S, Fairlie D, et al.
Int J Parasitol Drugs Drug Resist
. 2015 Jul;
5(3):117-26.
PMID: 26199860
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and...
4.
Hansen F, Sumanadasa S, Stenzel K, Duffy S, Meister S, Marek L, et al.
Eur J Med Chem
. 2014 Jun;
82:204-13.
PMID: 24904967
In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel...
5.
Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen F, et al.
Antimicrob Agents Chemother
. 2014 Apr;
58(7):3666-78.
PMID: 24733477
Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity;...
6.
Hansen F, Skinner-Adams T, Duffy S, Marek L, Sumanadasa S, Kuna K, et al.
ChemMedChem
. 2014 Feb;
9(3):665-70.
PMID: 24497437
Histone deacetylase (HDAC) inhibitors are an emerging class of potential antimalarial drugs. We investigated the antiplasmodial properties of 16 alkoxyurea-based HDAC inhibitors containing various cap and zinc binding groups (ZBGs)....
7.
Andrews K, Fisher G, Sumanadasa S, Skinner-Adams T, Moeker J, Lopez M, et al.
Bioorg Med Chem Lett
. 2013 Oct;
23(22):6114-7.
PMID: 24084158
Despite the urgent need for effective antimalarial drugs with novel modes of action no new chemical class of antimalarial drug has been approved for use since 1996. To address this,...
8.
Sumanadasa S, Goodman C, Lucke A, Skinner-Adams T, Sahama I, Haque A, et al.
Antimicrob Agents Chemother
. 2012 Apr;
56(7):3849-56.
PMID: 22508312
Histone deacetylase (HDAC) enzymes posttranslationally modify lysines on histone and nonhistone proteins and play crucial roles in epigenetic regulation and other important cellular processes. HDAC inhibitors (e.g., suberoylanilide hydroxamic acid...