Finn K Hansen
Overview
Explore the profile of Finn K Hansen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
84
Citations
826
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Stopper D, Biermann L, Watson P, Li J, Konig B, Gaynes M, et al.
J Med Chem
. 2025 Feb;
68(4):4426-4452.
PMID: 39946728
In this work, we synthesized a series of peptoid-based histone deacetylase (HDAC) inhibitors with variations in the linker region and zinc-binding groups. All compounds were investigated for their HDAC inhibition,...
2.
Wurnig S, Huber M, Weiler C, Baltrukevich H, Merten N, Stotzel I, et al.
J Med Chem
. 2025 Feb;
68(4):4308-4333.
PMID: 39937529
Intracellular ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in drug discovery. Here, we report the development of the fluorescent ligand Mz437 () targeting the CC chemokine receptor...
3.
Feller F, Honin I, Miranda M, Weber H, Henze S, Hanl M, et al.
J Med Chem
. 2025 Jan;
68(2):1824-1843.
PMID: 39804678
Targeted protein degradation (TPD) represents a promising alternative to conventional occupancy-driven protein inhibition. Despite the existence of more than 600 E3 ligases in the human proteome, so far only a...
4.
Zenz T, Jenke R, Thieme R, Kahl T, Borchardt H, Gockel I, et al.
Cancer Res Treat
. 2024 Dec;
PMID: 39668393
Purpose: HER2 inhibition represents a therapeutic approach with proven clinical efficacy in gastric cancer. However, resistance against HER2-directed therapeutics highlights the need for alternative approaches or drug combinations. Histone deacetylase...
5.
Stopper D, Buntrock S, Tan K, Pessanha de Carvalho L, Schaker-Hubner L, Held J, et al.
Eur J Med Chem
. 2024 Nov;
281:117045.
PMID: 39549507
In this study, we synthesized and evaluated novel histone deacetylase (HDAC) inhibitors derived from the clinical candidate quisinostat. A library of 16 compounds categorized in three novel chemotypes was rapidly...
6.
Bollmann L, Lange F, Hamacher A, Biermann L, Schaker-Hubner L, Hansen F, et al.
Cancers (Basel)
. 2024 Oct;
16(19).
PMID: 39409994
Background/objectives: Cisplatin is part of the first-line treatment of advanced urothelial carcinoma. Cisplatin resistance is a major problem but may be overcome by combination treatments such as targeting epigenetic aberrances....
7.
Kraft F, Biermann L, Schaker-Hubner L, Hanl M, Hamacher A, Kassack M, et al.
J Med Chem
. 2024 Oct;
67(19):17796-17819.
PMID: 39356226
In this work, we have synthesized a set of peptoid-based histone deacetylase inhibitors (HDACi) with a substituted hydrazide moiety as zinc-binding group. Subsequently, all compounds were evaluated in biochemical HDAC...
8.
Toledano-Pinedo M, Porro-Perez A, Schaker-Hubner L, Romero F, Dong M, Samadi A, et al.
J Med Chem
. 2024 Sep;
67(18):16533-16555.
PMID: 39256214
Herein, we describe the design, synthesis, and biological evaluation of 15 + hybrids. These ligands are polyfunctionalized indole derivatives developed by juxtaposing selected pharmacophoric moieties of and to act as...
9.
Stopper D, Pessanha de Carvalho L, De Souza M, Kponomaizoun C, Winzeler E, Held J, et al.
Eur J Med Chem
. 2024 Aug;
277:116782.
PMID: 39208744
Dynamics of epigenetic modifications such as acetylation and deacetylation of histone proteins have been shown to be crucial for the life cycle development and survival of Plasmodium falciparum, the deadliest...
10.
Fischle A, Lutsch M, Hubner F, Schaker-Hubner L, Schurmann L, Hansen F, et al.
Nat Prod Bioprospect
. 2024 Aug;
14(1):51.
PMID: 39177677
Apicidins are a class of naturally occurring cyclic tetrapeptides produced by few strains within the Fusarium genus. These secondary metabolites have gained significant attention due to their antiprotozoal activity through...