Stuart J Conway
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Explore the profile of Stuart J Conway including associated specialties, affiliations and a list of published articles.
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90
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1748
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Recent Articles
31.
Geddes B, Paramasivan P, Joffrin A, Thompson A, Christensen K, Jorrin B, et al.
Nat Commun
. 2019 Aug;
10(1):3430.
PMID: 31366919
The root microbiota is critical for agricultural yield, with growth-promoting bacteria able to solubilise phosphate, produce plant growth hormones, antagonise pathogens and fix N. Plants control the microorganisms in their...
32.
Rasmussen T, Rasmussen A, Yang L, Kaul C, Black S, Galbiati H, et al.
J Mol Biol
. 2019 Jun;
431(17):3339-3352.
PMID: 31173776
All membrane proteins have dynamic and intimate relationships with the lipids of the bilayer that may determine their activity. Mechanosensitive channels sense tension through their interaction with the lipids of...
33.
Schiedel M, Moroglu M, Ascough D, Chamberlain A, Kamps J, Sekirnik A, et al.
Angew Chem Int Ed Engl
. 2019 Jan;
58(50):17930-17952.
PMID: 30633431
Epigenetics is currently the focus of intense research interest across a broad range of disciplines due to its importance in a multitude of biological processes and disease states. Epigenetic functions...
34.
Collins S, Saha J, Bouchez L, Hammond E, Conway S
ACS Chem Biol
. 2018 Nov;
13(12):3354-3360.
PMID: 30451487
Hypoxia, a condition of reduced oxygen, occurs in a wide variety of biological contexts, including solid tumors and bacterial biofilms, which are relevant to human health. Consequently, the development of...
35.
Schiedel M, Conway S
Curr Opin Chem Biol
. 2018 Jun;
45:166-178.
PMID: 29958150
Lysine acetylation has emerged as a key post-translational modification found at many sites throughout the cell. It plays an important role in epigenetic processes, and more generally in the regulation...
36.
Phillips J, Butt L, Henderson C, Devonshire M, Healy J, Conway S, et al.
Nucleic Acids Res
. 2018 May;
46(14):e86.
PMID: 29846708
We are just beginning to unravel the myriad of interactions in which non-coding RNAs participate. The intricate RNA interactome is the foundation of many biological processes, including bacterial virulence and...
37.
Jennings L, Schiedel M, Hewings D, Picaud S, Laurin C, Bruno P, et al.
Bioorg Med Chem
. 2018 May;
26(11):2937-2957.
PMID: 29776834
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that...
38.
Mistry I, Thomas M, Calder E, Conway S, Hammond E
Int J Radiat Oncol Biol Phys
. 2017 Jul;
98(5):1183-1196.
PMID: 28721903
With the increasing incidence of cancer worldwide, the need for specific, effective therapies is ever more urgent. One example of targeted cancer therapeutics is hypoxia-activated prodrugs (HAPs), also known as...
39.
Pliotas C, Grayer S, Ekkerman S, Chan A, Healy J, Marius P, et al.
Biochemistry
. 2017 Jun;
56(32):4219-4234.
PMID: 28656748
Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and cofactors essential to protein stability, reactivity, or enzyme-substrate...
40.
OConnor L, Mistry I, Collins S, Folkes L, Brown G, Conway S, et al.
ACS Cent Sci
. 2017 Feb;
3(1):20-30.
PMID: 28149949
Azide-containing compounds have broad utility in organic synthesis and chemical biology. Their use as powerful tools for the labeling of biological systems has enabled insights into complex cellular functions. To...