Stuart J Conway
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Explore the profile of Stuart J Conway including associated specialties, affiliations and a list of published articles.
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90
Citations
1748
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Recent Articles
21.
Flynn N, Ward M, Schleiff M, Laurin C, Farmer R, Conway S, et al.
Metabolites
. 2021 Jul;
11(6).
PMID: 34203690
The 3,5-dimethylisoxazole motif has become a useful and popular acetyl-lysine mimic employed in isoxazole-containing bromodomain and extra-terminal (BET) inhibitors but may introduce the potential for bioactivations into toxic reactive metabolites....
22.
Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, et al.
Nat Chem
. 2021 Jun;
13(7):714.
PMID: 34103693
No abstract available.
23.
Skwarska A, Calder E, Sneddon D, Bolland H, Odyniec M, Mistry I, et al.
Cell Chem Biol
. 2021 Apr;
28(9):1258-1270.e13.
PMID: 33910023
Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue, represent a promising treatment strategy. We report...
24.
Favalli N, Bassi G, Pellegrino C, Millul J, De Luca R, Cazzamalli S, et al.
Nat Chem
. 2021 Apr;
13(6):540-548.
PMID: 33833446
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of small-molecule ligands for proteins. To investigate the impact of stereo- and regiochemistry on ligand discovery, we synthesized...
25.
Bassi G, Favalli N, Vuk M, Catalano M, Martinelli A, Trenner A, et al.
Adv Sci (Weinh)
. 2020 Nov;
7(22):2001970.
PMID: 33240760
A versatile and Lipinski-compliant DNA-encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB-DEL library, constructed...
26.
Laurin C, Bluck J, Chan A, Keller M, Boczek A, Scorah A, et al.
ACS Infect Dis
. 2020 Nov;
7(8):2238-2249.
PMID: 33203208
The () parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the parasite is complex and includes transitions between distinct life...
27.
Bowler E, Skwarska A, Wilson J, Ramachandran S, Bolland H, Easton A, et al.
iScience
. 2020 Nov;
23(11):101668.
PMID: 33134898
Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a...
28.
Conway S, Arimondo P, Arrowsmith C, Jin J, Luo C, Meanwell N, et al.
J Med Chem
. 2020 Oct;
63(21):12129-12130.
PMID: 33090784
No abstract available.
29.
Catalano M, Moroglu M, Balbi P, Mazzieri F, Clayton J, Andrews K, et al.
ChemMedChem
. 2020 Jul;
15(18):1752-1756.
PMID: 32686307
DNA-encoded chemical libraries (DECLs) are collections of chemical moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e.,...
30.
Conway S
J Med Chem
. 2020 Mar;
63(6):2802-2806.
PMID: 32157887
Heterobifunctional molecules, which recruit E3 ligases to ubiquitinate a target protein of interest, have found wide application as both biological tools and molecules with the potential to have clinical effects....