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Martin D Bootman

Explore the profile of Martin D Bootman including associated specialties, affiliations and a list of published articles. Areas
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Articles 94
Citations 6869
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Recent Articles
1.
Dragoni S, Moccia F, Bootman M
Cold Spring Harb Perspect Biol . 2024 Nov; 17(2). PMID: 39586624
The inner blood-retinal barrier (iBRB) protects the retinal vasculature from the peripheral circulation. Endothelial cells (ECs) are the core component of the iBRB; their close apposition and linkage via tight...
2.
Lemos F, de Ridder I, Wagner L, Bootman M, Bultynck G, Yule D, et al.
Biochim Biophys Acta Mol Cell Res . 2024 Jul; 1871(7):119796. PMID: 39038610
Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme interacting with the inositol 1,4,5-trisphosphate receptor (IPR). This interaction suppresses IPR-mediated cytosolic [Ca] rises. As PKM2 exists in monomeric, dimeric and...
3.
Brohus M, Bootman M, Bultynck G
Bioessays . 2024 May; 46(7):e2400017. PMID: 38713171
This article reflects on sustainability in the context of scientific conferences with emphasis on environmental, diversity, inclusivity, and intellectual aspects. We argue that it is imperative to embrace sustainability as...
4.
Lemos F, de Ridder I, Bootman M, Bultynck G, Parys J
Cells . 2023 Nov; 12(21). PMID: 37947604
Pyruvate kinase M (PKM) 2 was described to interact with the inositol 1,4,5-trisphosphate (IP) receptor (IPR) and suppress its activity. To further investigate the physiological importance of the PKM2:IPR interaction,...
5.
Sneyers F, Speelman-Rooms F, Verhelst S, Bootman M, Bultynck G
Biochim Biophys Acta Mol Cell Res . 2023 Sep; 1871(2):119589. PMID: 37739271
Intracellular Ca signals play a vital role in a broad range of cell biological and physiological processes in all eukaryotic cell types. Dysregulation of Ca signaling has been implicated in...
6.
Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, et al.
Cell Death Dis . 2023 Sep; 14(9):600. PMID: 37684238
Intracellular Ca signals control several physiological and pathophysiological processes. The main tool to chelate intracellular Ca is intracellular BAPTA (BAPTA), usually introduced into cells as a membrane-permeant acetoxymethyl ester (BAPTA-AM)....
7.
Silvestri R, Nicoli V, Gangadharannambiar P, Crea F, Bootman M
Nat Rev Urol . 2023 Mar; 20(9):524-543. PMID: 36964408
Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling mechanisms. In particular, altered calcium signalling is emerging as one of the most widespread adaptations in cancer cells. Remodelling of...
8.
Patel S, Bootman M, Rossi A, Rahman T, Marchant J
Sci Signal . 2022 Nov; 15(762):eadf0308. PMID: 36445939
On 2 September 2022, about 85 scientists gathered in person at Queens' College in Cambridge, UK, for a scientific meeting to celebrate the career of Colin W. Taylor of Cambridge...
9.
Lavik A, McColl K, Lemos F, Kerkhofs M, Zhong F, Harr M, et al.
Biochim Biophys Acta Mol Cell Res . 2022 Jan; 1869(4):119206. PMID: 35026348
Pyruvate kinase isoform M2 (PKM2) is a rate-limiting glycolytic enzyme that is widely expressed in embryonic tissues. The expression of PKM2 declines in some tissues following embryogenesis, while other pyruvate...
10.
Needs S, Bootman M, Grotzke J, Kramer H, Allman S
FEBS J . 2022 Jan; 289(11):3115-3131. PMID: 34995415
The polycaspase inhibitor Z-VAD-fmk acts as an inhibitor of peptide: N-glycanase (NGLY1), an endoglycosidase which cleaves N-linked glycans from glycoproteins exported from the endoplasmic reticulum (ER) during ER-associated degradation (ERAD)....