Stuart A Rushworth
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Explore the profile of Stuart A Rushworth including associated specialties, affiliations and a list of published articles.
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75
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2165
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Recent Articles
1.
Steverding D, Rushworth S, Hurle G, Antoszczak M, Sulik M, Huczynski A, et al.
Molecules
. 2024 Dec;
29(23).
PMID: 39683767
Salinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of . The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx...
2.
Wojtowicz E, Hampton K, Moreno-Gonzalez M, Utting C, Lan Y, Ruiz P, et al.
Commun Biol
. 2024 Sep;
7(1):1219.
PMID: 39349819
Western diets are the underlying cause of metabolic and liver diseases. Recent trend to limit the consumption of protein-rich animal products has become more prominent. This dietary change entails decreased...
3.
Moreno-Gonzalez M, Hampton K, Ruiz P, Beasy G, Nagies F, Parker A, et al.
JHEP Rep
. 2024 Sep;
6(10):101159.
PMID: 39314550
Background & Aims: Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, being detrimental in biliary cells and...
4.
Fowler-Shorten D, Hellmich C, Markham M, Bowles K, Rushworth S
Blood Rev
. 2024 Mar;
65:101195.
PMID: 38523032
B-cell lymphoma-2 (BCL-2) family proteins are fundamental regulators of the intrinsic apoptotic pathway which modulate cellular fate. In many haematological malignancies, overexpression of anti-apoptotic factors (BCL-2, BCL-XL and MCL-1) circumvent...
5.
Steverding D, Tinson R, Piras M, Wren S, Rushworth S, Searcey M, et al.
Exp Parasitol
. 2024 Mar;
260:108744.
PMID: 38513971
Suramin was the first effective drug for the treatment of human African sleeping sickness. Structural analogues of the trypanocide have previously been shown to be potent inhibitors of several enzymes....
6.
Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes
Johnson B, Cosson M, Tsansizi L, Holmes T, Gilmore T, Hampton K, et al.
Cell Rep
. 2024 Jan;
43(1):113668.
PMID: 38198277
Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that...
7.
Fowler-Shorten D, Maynard R, Hampton K, Altera A, Markham M, Ehikioya M, et al.
Haematologica
. 2024 Jan;
109(5):1576-1581.
PMID: 38186347
No abstract available.
8.
Wojtowicz E, Mistry J, Uzun V, Hellmich C, Scoones A, Chin D, et al.
Genome Biol
. 2023 Jun;
24(1):152.
PMID: 37370129
Background: Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. Results: We use lentiviral...
9.
Mistry J, Rushworth S
Methods Mol Biol
. 2023 May;
2675:43-49.
PMID: 37258754
In vivo imaging enables the detection and visualization of many different processes occurring within the body. Fatty acid uptake is a fundamental cellular process which is essential for the use...
10.
Mincarelli L, Uzun V, Wright D, Scoones A, Rushworth S, Haerty W, et al.
Commun Biol
. 2023 May;
6(1):558.
PMID: 37225862
Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed progenitor, marked by changes in gene expression. However, many of these approaches...