Charlotte Hellmich
Overview
Explore the profile of Charlotte Hellmich including associated specialties, affiliations and a list of published articles.
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24
Citations
400
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Recent Articles
1.
Wojtowicz E, Hampton K, Moreno-Gonzalez M, Utting C, Lan Y, Ruiz P, et al.
Commun Biol
. 2024 Sep;
7(1):1219.
PMID: 39349819
Western diets are the underlying cause of metabolic and liver diseases. Recent trend to limit the consumption of protein-rich animal products has become more prominent. This dietary change entails decreased...
2.
Moreno-Gonzalez M, Hampton K, Ruiz P, Beasy G, Nagies F, Parker A, et al.
JHEP Rep
. 2024 Sep;
6(10):101159.
PMID: 39314550
Background & Aims: Senescence has been reported to have differential functions in cholangiocytes and hepatic stellate cells (HSCs) during human and murine cholestatic disease, being detrimental in biliary cells and...
3.
Fowler-Shorten D, Hellmich C, Markham M, Bowles K, Rushworth S
Blood Rev
. 2024 Mar;
65:101195.
PMID: 38523032
B-cell lymphoma-2 (BCL-2) family proteins are fundamental regulators of the intrinsic apoptotic pathway which modulate cellular fate. In many haematological malignancies, overexpression of anti-apoptotic factors (BCL-2, BCL-XL and MCL-1) circumvent...
4.
Fowler-Shorten D, Maynard R, Hampton K, Altera A, Markham M, Ehikioya M, et al.
Haematologica
. 2024 Jan;
109(5):1576-1581.
PMID: 38186347
No abstract available.
5.
Wojtowicz E, Mistry J, Uzun V, Hellmich C, Scoones A, Chin D, et al.
Genome Biol
. 2023 Jun;
24(1):152.
PMID: 37370129
Background: Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. Results: We use lentiviral...
6.
Jibril A, Hellmich C, Wojtowicz E, Hampton K, Maynard R, De Silva R, et al.
Blood
. 2023 Mar;
141(25):3065-3077.
PMID: 36888932
Mitochondrial damage-associated molecular patterns (mtDAMPs) include proteins, lipids, metabolites, and DNA and have various context-specific immunoregulatory functions. Cell-free mitochondrial DNA (mtDNA) is recognized via pattern recognition receptors and is a...
7.
Hellmich C, Wojtowicz E
Front Immunol
. 2022 Oct;
13:1003006.
PMID: 36211413
Normal bone marrow (BM) homeostasis ensures consistent production of progenitor cells and mature blood cells. This requires a reliable supply of nutrients in particular free fatty acids, carbohydrates and protein....
8.
Maynard R, Hellmich C, Bowles K, Rushworth S
Front Oncol
. 2022 Jul;
12:924567.
PMID: 35847950
Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML predominantly affects older people and outcomes, particularly in...
9.
Hellmich C, Wojtowicz E, Moore J, Mistry J, Jibril A, Johnson B, et al.
Blood Adv
. 2022 May;
7(2):256-268.
PMID: 35622970
Rapid and effective leukocyte response to infection is a fundamental function of the bone marrow (BM). However, with increasing age, this response becomes impaired, resulting in an increased burden of...
10.
Kumar P, Saad M, Hellmich C, Mistry J, Moore J, Conway S, et al.
Br J Cancer
. 2022 Mar;
127(1):69-78.
PMID: 35347324
Introduction: Progress in the knowledge of metabolic interactions between cancer and its microenvironment is ongoing and may lead to novel therapeutic approaches. Until recently, melanoma was considered a glycolytic tumour...