Manar S Shafat
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Explore the profile of Manar S Shafat including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
657
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Recent Articles
1.
Mehra V, Agliardi G, Dias Alves Pinto J, Shafat M, Garai A, Green L, et al.
J Immunother Cancer
. 2023 Sep;
11(9).
PMID: 37709295
Background: AUTO1 is a fast off-rate CD19-targeting chimeric antigen receptor (CAR), which has been successfully tested in adult lymphoblastic leukemia. Tscm/Tcm-enriched CAR-T populations confer the best expansion and persistence, but...
2.
Shafat M, Rufaie E, Watkins J
Pharmacogenomics J
. 2021 Mar;
21(3):390-401.
PMID: 33731882
Certain breast and ovarian cancers are characterised by high levels of chromosomal instability. We established a suite of eleven SNP array-based signatures of various forms of chromosomal instability. To understand...
3.
Shafat M, Mehra V, Peggs K, Roddie C
Front Immunol
. 2020 Aug;
11:1694.
PMID: 32849591
Cytomegalovirus (CMV) infection is common following allogeneic hematopoietic stem cell transplant (HSCT) and is a major cause of morbidity and increased mortality. Whilst pharmacotherapy can be effective in the prevention...
4.
Abdul-Aziz A, Sun Y, Hellmich C, Marlein C, Mistry J, Forde E, et al.
Blood
. 2018 Nov;
133(5):446-456.
PMID: 30401703
Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest...
5.
Piddock R, Marlein C, Abdul-Aziz A, Shafat M, Auger M, Bowles K, et al.
J Hematol Oncol
. 2018 May;
11(1):66.
PMID: 29769142
Conclusions: Our presented findings show that MM-derived MIF causes BMSC secretion of IL-6 and IL-8 via BMSC cMYC. Furthermore, we show that the cMYC inhibitor JQ1 can reduce BMSC secreted...
6.
Abdul-Aziz A, Shafat M, Sun Y, Marlein C, Piddock R, Robinson S, et al.
Oncogene
. 2018 Mar;
37(20):2676-2686.
PMID: 29487418
Approximately 80% of patients diagnosed with acute myeloid leukemia (AML) die as a consequence of failure to eradicate the tumor from the bone marrow microenvironment. We have recently shown that...
7.
Marlein C, Zaitseva L, Piddock R, Robinson S, Edwards D, Shafat M, et al.
Blood
. 2017 Jul;
130(14):1649-1660.
PMID: 28733324
Improvements in the understanding of the metabolic cross-talk between cancer and its microenvironment are expected to lead to novel therapeutic approaches. Acute myeloid leukemia (AML) cells have increased mitochondria compared...
8.
Shafat M, Gnaneswaran B, Bowles K, Rushworth S
Blood Rev
. 2017 Mar;
31(5):277-286.
PMID: 28318761
Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically heterogeneous set of diseases, which are characterised by an increased growth of abnormal myeloid progenitor cells within the bone marrow...
9.
Shafat M, Oellerich T, Mohr S, Robinson S, Edwards D, Marlein C, et al.
Blood
. 2017 Jan;
129(10):1320-1332.
PMID: 28049638
Despite currently available therapies, most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for the survival and proliferation of cancer cells; accordingly, we...
10.
Abdul-Aziz A, Shafat M, Mehta T, Di Palma F, Lawes M, Rushworth S, et al.
Cancer Res
. 2016 Nov;
77(2):303-311.
PMID: 27872094
Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue microenvironment plays a...