Stuart A Rushworth
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Explore the profile of Stuart A Rushworth including associated specialties, affiliations and a list of published articles.
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75
Citations
2165
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Recent Articles
11.
Jibril A, Hellmich C, Wojtowicz E, Hampton K, Maynard R, De Silva R, et al.
Blood
. 2023 Mar;
141(25):3065-3077.
PMID: 36888932
Mitochondrial damage-associated molecular patterns (mtDAMPs) include proteins, lipids, metabolites, and DNA and have various context-specific immunoregulatory functions. Cell-free mitochondrial DNA (mtDNA) is recognized via pattern recognition receptors and is a...
12.
Mistry J, Bowles K, Rushworth S
Exp Hematol
. 2022 Oct;
117:1-8.
PMID: 36223830
Metabolism impacts all cellular functions and plays a fundamental role in physiology. Metabolic regulation of hematopoiesis is dynamically regulated under steady-state and stress conditions. It is clear that hematopoietic stem...
13.
Maynard R, Hellmich C, Bowles K, Rushworth S
Front Oncol
. 2022 Jul;
12:924567.
PMID: 35847950
Acute myeloid leukaemia (AML) is a highly proliferative cancer characterised by infiltration of immature haematopoietic cells in the bone marrow (BM). AML predominantly affects older people and outcomes, particularly in...
14.
Hellmich C, Wojtowicz E, Moore J, Mistry J, Jibril A, Johnson B, et al.
Blood Adv
. 2022 May;
7(2):256-268.
PMID: 35622970
Rapid and effective leukocyte response to infection is a fundamental function of the bone marrow (BM). However, with increasing age, this response becomes impaired, resulting in an increased burden of...
15.
Kumar P, Saad M, Hellmich C, Mistry J, Moore J, Conway S, et al.
Br J Cancer
. 2022 Mar;
127(1):69-78.
PMID: 35347324
Introduction: Progress in the knowledge of metabolic interactions between cancer and its microenvironment is ongoing and may lead to novel therapeutic approaches. Until recently, melanoma was considered a glycolytic tumour...
16.
Johnson B, Reinhold J, Holmes T, Moore J, Cowell V, Bernardo A, et al.
Metabolites
. 2022 Jan;
12(1).
PMID: 35050131
Cardiomyocytes rely on specialised metabolism to meet the high energy demand of the heart. During heart development, metabolism matures and shifts from the predominant utilisation of glycolysis and glutamine oxidation...
17.
Moore J, Mistry J, Hellmich C, Horton R, Wojtowicz E, Jibril A, et al.
J Clin Invest
. 2022 Jan;
132(5).
PMID: 34990402
The bone marrow (BM) microenvironment regulates acute myeloid leukemia (AML) initiation, proliferation, and chemotherapy resistance. Following cancer cell death, a growing body of evidence suggests an important role for remaining...
18.
Isaacs-Ten A, Moreno-Gonzalez M, Bone C, Martens A, Bernuzzi F, Ludwig T, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Dec;
13(4):1019-1039.
PMID: 34952202
Background & Aims: Inflammation is the hallmark of chronic liver disease. Metabolism is a key determinant to regulate the activation of immune cells. Here, we define the role of sirtuin...
19.
Mistry J, Hellmich C, Moore J, Jibril A, Macaulay I, Moreno-Gonzalez M, et al.
Nat Commun
. 2021 Dec;
12(1):7130.
PMID: 34880245
Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is...
20.
Moore J, Mistry J, Rushworth S
Adv Exp Med Biol
. 2021 Oct;
1329:181-203.
PMID: 34664240
The bone marrow (BM) is a complex organ located within the cavities of bones. The main function of the BM is to produce all the blood cells required for a...