David W Christianson
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Explore the profile of David W Christianson including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Osika K, Gaynes M, Christianson D
bioRxiv
. 2025 Feb;
PMID: 39990494
Drimenol synthase from (AsDMS) is a highly unusual bifunctional sesquiterpene synthase that integrates two distinct, sequential isoprenoid processing activities within a single polypeptide chain. AsDMS catalyzes the class II cyclization...
2.
Goulart Stollmaier J, Czarnecki B, Christianson D
J Am Chem Soc
. 2025 Feb;
147(8):6373-6377.
PMID: 39957581
Organoselenocyanates have attracted considerable attention in recent years due to their therapeutic potential and versatility in medicinal chemistry. Here, we report on the mechanism of inhibition by 5-phenylcarbamoylpentyl selenocyanide (SelSA-2),...
3.
Stopper D, Biermann L, Watson P, Li J, Konig B, Gaynes M, et al.
J Med Chem
. 2025 Feb;
68(4):4426-4452.
PMID: 39946728
In this work, we synthesized a series of peptoid-based histone deacetylase (HDAC) inhibitors with variations in the linker region and zinc-binding groups. All compounds were investigated for their HDAC inhibition,...
4.
Shimogawa M, Li M, Park G, Ramirez J, Lee H, Watson P, et al.
bioRxiv
. 2025 Feb;
PMID: 39896484
Aggregates of α-synuclein (αS) are hallmarks of synucleinopathies, including Parkinson's Disease (PD) and Multiple System Atrophy (MSA). We have recently shown that αS lysine acetylation in the soluble monomer pool...
5.
Christianson D, Czarnecki B, Goulart Stollmaier J, Czarnecki B
bioRxiv
. 2025 Jan;
PMID: 39803514
Organoselenocyanates have attracted considerable attention in recent years due to their therapeutic potential and versatility in medicinal chemistry. Here, we report on the mechanism of inhibition by 5-phenylcarbamoylpentyl selenocyanide (SelSA-2),...
6.
Wenger E, Christianson D
bioRxiv
. 2024 Dec;
PMID: 39677668
An unusual family of bifunctional terpene synthases has been discovered in which both catalytic domains - a prenyltransferase and a cyclase - are connected by a long, flexible linker. These...
7.
Gaynes M, Osika K, Christianson D
Biochemistry
. 2024 Nov;
63(23):3147-3159.
PMID: 39527408
Sabinene is a plant natural product with a distinctive strained [3.1.0] bicyclic ring system that is used commercially as a spicy and pine-like fragrance with citrus undertones. This unusual monoterpene...
8.
Goulart Stollmaier J, Watson P, Christianson D
ACS Med Chem Lett
. 2024 Oct;
15(10):1715-1723.
PMID: 39411528
Histone deacetylase 10 (HDAC10) is unique among the greater HDAC family due to its unusually narrow substrate specificity as a polyamine deacetylase, specifically as an -acetylspermidine hydrolase. Polyamines are essential...
9.
Wenger E, Schultz K, Marmorstein R, Christianson D
Proc Natl Acad Sci U S A
. 2024 Oct;
121(41):e2408064121.
PMID: 39365814
Fusicoccadiene synthase from (PaFS) is a bifunctional terpene synthase. It contains a prenyltransferase (PT) domain that generates geranylgeranyl diphosphate (GGPP) from dimethylallyl diphosphate and three equivalents of isopentenyl diphosphate, and...
10.
Wenger E, Christianson D
Methods Enzymol
. 2024 Jun;
699:89-119.
PMID: 38942517
Prenyltransferases are terpene synthases that combine 5-carbon precursor molecules into linear isoprenoids of varying length that serve as substrates for terpene cyclases, enzymes that catalyze fascinating cyclization reactions to form...