Stefanie Barthel
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Explore the profile of Stefanie Barthel including associated specialties, affiliations and a list of published articles.
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15
Citations
162
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Recent Articles
1.
Diehl C, Soberon V, Baygun S, Chu Y, Mandelbaum J, Kraus L, et al.
Immunity
. 2024 Dec;
58(1):124-142.e15.
PMID: 39729992
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated...
2.
Papargyriou A, Najajreh M, Cook D, Maurer C, Barthel S, Messal H, et al.
Nat Biomed Eng
. 2024 Dec;
PMID: 39658630
In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by organoid models of...
3.
Urbauer E, Aguanno D, Mindermann N, Omer H, Metwaly A, Krammel T, et al.
Cell Host Microbe
. 2024 Jul;
32(8):1347-1364.e10.
PMID: 39013472
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting the mitochondrial chaperone,...
4.
Menche C, Schuhwerk H, Armstark I, Gupta P, Fuchs K, van Roey R, et al.
EMBO Rep
. 2024 Jun;
25(8):3406-3431.
PMID: 38937629
The EMT-transcription factor ZEB1 is heterogeneously expressed in tumor cells and in cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC). While ZEB1 in tumor cells regulates metastasis and therapy resistance, its...
5.
Wang X, Istvanffy R, Ye L, Teller S, Laschinger M, Diakopoulos K, et al.
J Clin Invest
. 2023 Aug;
133(21).
PMID: 37607005
Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but...
6.
Swietlik J, Barthel S, Falcomata C, Fink D, Sinha A, Cheng J, et al.
Nat Commun
. 2023 May;
14(1):2642.
PMID: 37156840
Cell-selective proteomics is a powerful emerging concept to study heterocellular processes in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms and biomarkers has been hindered by low proteome...
7.
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Barthel S, Falcomata C, Rad R, Theis F, Saur D
Nat Cancer
. 2023 Mar;
4(4):454-467.
PMID: 36959420
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive tumor microenvironment. Recent advances in high-resolution single-cell sequencing and spatial transcriptomics...
8.
Falcomata C, Barthel S, Schneider G, Rad R, Schmidt-Supprian M, Saur D
Cancer Discov
. 2023 Jan;
13(2):278-297.
PMID: 36622087
Significance: Immunosuppression is an almost universal hallmark of pancreatic cancer, although this tumor entity is highly heterogeneous across its different subtypes and phenotypes. Here, we provide evidence that the diverse...
9.
Schmitt C, Saur D, Barthel S, Falcomata C
J Vis Exp
. 2022 Oct;
(188).
PMID: 36282716
Pancreatic ductal adenocarcinoma (PDAC) is a very complex disease characterized by a heterogeneous tumor microenvironment made up of a diverse stroma, immune cells, vessels, nerves, and extracellular matrix components. Over...
10.
Giansanti P, Samaras P, Bian Y, Meng C, Coluccio A, Frejno M, et al.
Nat Methods
. 2022 Jun;
19(7):803-811.
PMID: 35710609
The laboratory mouse ranks among the most important experimental systems for biomedical research and molecular reference maps of such models are essential informational tools. Here, we present a quantitative draft...