Roman Maresch
Overview
Explore the profile of Roman Maresch including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
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Articles
12
Citations
710
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Recent Articles
1.
Kaltenbacher T, Loprich J, Maresch R, Weber J, Muller S, Oellinger R, et al.
Nat Protoc
. 2022 Mar;
17(4):1142-1188.
PMID: 35288718
Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic stem cells. Here, we describe methods for rapid and...
2.
Falcomata C, Barthel S, Widholz S, Schneeweis C, Montero J, Toska A, et al.
Nat Cancer
. 2022 Feb;
3(3):318-336.
PMID: 35122074
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene...
3.
Schick M, Zhang L, Maurer S, Maurer H, Isaakaidis K, Schneider L, et al.
Nat Commun
. 2022 Jan;
13(1):281.
PMID: 35022408
SUMOylation is a post-translational modification of proteins that regulates these proteins' localization, turnover or function. Aberrant SUMOylation is frequently found in cancers but its origin remains elusive. Using a genome-wide...
4.
Falcomata C, Barthel S, Ulrich A, Diersch S, Veltkamp C, Rad L, et al.
Cancer Discov
. 2021 Jul;
11(12):3158-3177.
PMID: 34282029
Significance: We used the first genetically engineered mouse model for extrahepatic bile duct carcinoma to identify cancer genes by genome-wide transposon-based mutagenesis screening. Thereby, we show that PI3K signaling output...
5.
Dantes Z, Yen H, Pfarr N, Winter C, Steiger K, Muckenhuber A, et al.
JCI Insight
. 2020 Jul;
5(15).
PMID: 32614802
One of the major challenges in using pancreatic cancer patient-derived organoids (PDOs) in precision oncology is the time from biopsy to functional characterization. This is particularly true for endoscopic ultrasound-guided...
6.
Lange S, Engleitner T, Mueller S, Maresch R, Zwiebel M, Gonzalez-Silva L, et al.
Nat Protoc
. 2020 Jan;
15(2):266-315.
PMID: 31907453
Mouse models of human cancer have transformed our ability to link genetics, molecular mechanisms and phenotypes. Both reverse and forward genetics in mice are currently gaining momentum through advances in...
7.
Mueller S, Engleitner T, Maresch R, Zukowska M, Lange S, Kaltenbacher T, et al.
Nature
. 2018 Jan;
554(7690):62-68.
PMID: 29364867
The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical...
8.
Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Ollinger R, et al.
Nature
. 2017 Nov;
553(7687):238.
PMID: 29186126
This corrects the article DOI: 10.1038/nature24649.
9.
Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, Ollinger R, et al.
Nature
. 2017 Nov;
552(7683):121-125.
PMID: 29143824
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterized by genetic...
10.
Maresch R, Mueller S, Veltkamp C, Ollinger R, Friedrich M, Heid I, et al.
Nat Commun
. 2016 Feb;
7:10770.
PMID: 26916719
Mouse transgenesis has provided fundamental insights into pancreatic cancer, but is limited by the long duration of allele/model generation. Here we show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas...