Stefanie Barthel
Overview
Explore the profile of Stefanie Barthel including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
162
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0
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Recent Articles
11.
Kaltenbacher T, Loprich J, Maresch R, Weber J, Muller S, Oellinger R, et al.
Nat Protoc
. 2022 Mar;
17(4):1142-1188.
PMID: 35288718
Genetically engineered mouse models (GEMMs) transformed the study of organismal disease phenotypes but are limited by their lengthy generation in embryonic stem cells. Here, we describe methods for rapid and...
12.
Falcomata C, Barthel S, Widholz S, Schneeweis C, Montero J, Toska A, et al.
Nat Cancer
. 2022 Feb;
3(3):318-336.
PMID: 35122074
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like mesenchymal PDAC, which is driven by allelic imbalance, increased gene...
13.
Falcomata C, Barthel S, Ulrich A, Diersch S, Veltkamp C, Rad L, et al.
Cancer Discov
. 2021 Jul;
11(12):3158-3177.
PMID: 34282029
Significance: We used the first genetically engineered mouse model for extrahepatic bile duct carcinoma to identify cancer genes by genome-wide transposon-based mutagenesis screening. Thereby, we show that PI3K signaling output...
14.
Barthel S, Schneider G, Saur D
EMBO J
. 2020 Apr;
39(9):e104759.
PMID: 32236961
Epithelial differentiation of normal and tumor cells is orchestrated by lineage-determining transcriptional regulatory networks that enforce cell identity. Recent research by Kalisz et al (2020) in the EMBO Journal elucidates...
15.
Falcomata C, Barthel S, Schneider G, Saur D, Veltkamp C
Curr Opin Genet Dev
. 2019 May;
54:97-104.
PMID: 31078084
Molecular profiling of cancer patients and modelling of human cancer in mice revealed cell type and tissue-specific differences in tumor development and evolution. However, the context-dependent determinants of cancer remain...