Marc Schmidt-Supprian
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Explore the profile of Marc Schmidt-Supprian including associated specialties, affiliations and a list of published articles.
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103
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6281
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Recent Articles
1.
Antoniolli M, Solovey M, Hildebrand J, Freyholdt T, Strobl C, Bararia D, et al.
Cell Death Differ
. 2025 Jan;
PMID: 39843653
The cell death receptor FAS and its ligand (FASLG) play crucial roles in the selection of B cells during the germinal center (GC) reaction. Failure to eliminate potentially harmful B...
2.
Diehl C, Soberon V, Baygun S, Chu Y, Mandelbaum J, Kraus L, et al.
Immunity
. 2024 Dec;
58(1):124-142.e15.
PMID: 39729992
B cell immunity carries the inherent risk of deviating into autoimmunity and malignancy, which are both strongly associated with genetic variants or alterations that increase immune signaling. Here, we investigated...
3.
Lalle G, Lautraite R, Bouherrou K, Plaschka M, Pignata A, Voisin A, et al.
J Exp Med
. 2024 Apr;
221(6).
PMID: 38563819
The outcome of cancer and autoimmunity is often dictated by the effector functions of CD4+ conventional T cells (Tconv). Although activation of the NF-κB signaling pathway has long been implicated...
4.
Babushku T, Lechner M, Ehrenberg S, Rambold U, Schmidt-Supprian M, Yates A, et al.
Nat Commun
. 2024 Mar;
15(1):1960.
PMID: 38438375
Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this differentiation pathway is still elusive. Here, we...
5.
Montero J, Trozzo R, Sugden M, Ollinger R, Belka A, Zhigalova E, et al.
Nat Methods
. 2024 Feb;
21(4):584-596.
PMID: 38409225
Although long noncoding RNAs (lncRNAs) dominate the transcriptome, their functions are largely unexplored. The extensive overlap of lncRNAs with coding and regulatory sequences restricts their systematic interrogation by DNA-directed perturbation....
6.
Griger J, Widholz S, Jesinghaus M, de Andrade Kratzig N, Lange S, Engleitner T, et al.
Cancer Cell
. 2023 Jun;
41(7):1327-1344.e10.
PMID: 37352862
Gastric neuroendocrine carcinomas (G-NEC) are aggressive malignancies with poorly understood biology and a lack of disease models. Here, we use genome sequencing to characterize the genomic landscapes of human G-NEC...
7.
Kaltenbach L, Martzloff P, Bambach S, Aizarani N, Mihlan M, Gavrilov A, et al.
Nat Immunol
. 2023 Apr;
24(6):915-924.
PMID: 37081147
Immune cell locomotion is associated with amoeboid migration, a flexible mode of movement, which depends on rapid cycles of actin polymerization and actomyosin contraction. Many immune cells do not necessarily...
8.
Fischer A, Lersch R, de Andrade Kratzig N, Strong A, Friedrich M, Weber J, et al.
Cell Genom
. 2023 Mar;
3(3):100276.
PMID: 36950387
In contrast to mono- or biallelic loss of tumor-suppressor function, effects of discrete gene dysregulations, as caused by non-coding (epi)genome alterations, are poorly understood. Here, by perturbing the regulatory genome...
9.
Rohwedder I, Wackerbarth L, Heinig K, Ballweg A, Altstatter J, Ripphahn M, et al.
JCI Insight
. 2023 Jan;
8(4).
PMID: 36633909
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with...
10.
Falcomata C, Barthel S, Schneider G, Rad R, Schmidt-Supprian M, Saur D
Cancer Discov
. 2023 Jan;
13(2):278-297.
PMID: 36622087
Significance: Immunosuppression is an almost universal hallmark of pancreatic cancer, although this tumor entity is highly heterogeneous across its different subtypes and phenotypes. Here, we provide evidence that the diverse...