Sotiria Tavoulari
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Explore the profile of Sotiria Tavoulari including associated specialties, affiliations and a list of published articles.
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21
Citations
543
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Recent Articles
1.
Tavoulari S, Lacabanne D, Pereira G, Thangaratnarajah C, King M, He J, et al.
Mol Metab
. 2024 Oct;
90():102047.
PMID: 39419476
Objective: Citrin, the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, because it consists of three domains and forms a homo-dimer. Each...
2.
Alexander S, Fabbro D, Kelly E, Mathie A, Peters J, Veale E, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S374-S469.
PMID: 38123156
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
3.
Tavoulari S, Sichrovsky M, Kunji E
Acta Physiol (Oxf)
. 2023 Jun;
238(4):e14016.
PMID: 37366179
The mitochondrial pyruvate carrier (MPC) resides in the mitochondrial inner membrane, where it links cytosolic and mitochondrial metabolism by transporting pyruvate produced in glycolysis into the mitochondrial matrix. Due to...
4.
Mavridou V, King M, Tavoulari S, Ruprecht J, Palmer S, Kunji E
Nat Commun
. 2022 Jun;
13(1):3585.
PMID: 35739110
Mitochondrial ADP/ATP carriers import ADP into the mitochondrial matrix and export ATP to the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic- and matrix-open states have confirmed an...
5.
Tavoulari S, Lacabanne D, Thangaratnarajah C, Kunji E
Trends Endocrinol Metab
. 2022 Jun;
33(8):539-553.
PMID: 35725541
Citrin deficiency is a pan-ethnic and highly prevalent mitochondrial disease with three different stages: neonatal intrahepatic cholestasis (NICCD), a relatively mild adaptation stage, and type II citrullinemia in adulthood (CTLN2)....
6.
Tavoulari S, Schirris T, Mavridou V, Thangaratnarajah C, King M, Jones D, et al.
Mol Metab
. 2022 Mar;
60:101469.
PMID: 35278701
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. A range of...
7.
King M, Tavoulari S, Mavridou V, King A, Mifsud J, Kunji E
Int J Mol Sci
. 2020 Dec;
21(23.
PMID: 33255957
is a clinically important eukaryotic parasite that causes the disease cryptosporidiosis, which manifests with gastroenteritis-like symptoms. The protist has mitosomes, which are organelles of mitochondrial origin that have only been...
8.
Tavoulari S, Thangaratnarajah C, Mavridou V, Harbour M, Martinou J, Kunji E
EMBO J
. 2019 Apr;
38(10).
PMID: 30979775
The mitochondrial pyruvate carrier (MPC) is critical for cellular homeostasis, as it is required in central metabolism for transporting pyruvate from the cytosol into the mitochondrial matrix. MPC has been...
9.
Zhang Y, Tavoulari S, Sinning S, Aleksandrova A, Forrest L, Rudnick G
Proc Natl Acad Sci U S A
. 2018 Sep;
115(38):E8854-E8862.
PMID: 30181291
The coupled transport of ions and substrates allows transporters to accumulate substrates using the energy of transmembrane ion gradients and electrical potentials. During transport, conformational changes that switch accessibility of...
10.
Kunji E, Aleksandrova A, King M, Majd H, Ashton V, Cerson E, et al.
Biochim Biophys Acta
. 2016 Oct;
1863(12):3169.
PMID: 27713079
No abstract available.