Sookhee Ha
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Explore the profile of Sookhee Ha including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
744
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Recent Articles
1.
Ng S, Brueckner A, Bahmanjah S, Deng Q, Johnston J, Ge L, et al.
J Med Chem
. 2022 Jul;
PMID: 35853179
Recent evidence suggests that deletion of STUB1─a pivotal negative regulator of interferon-γ sensing─may potentially clear malignant cells. However, current studies rely primarily on genetic approaches, as pharmacological inhibitors of STUB1...
2.
Petrilli W, Adam G, Erdmann R, Abeywickrema P, Agnani V, Ai X, et al.
Cell Chem Biol
. 2021 Feb;
28(2):243.
PMID: 33607006
No abstract available.
3.
Petrilli W, Adam G, Erdmann R, Abeywickrema P, Agnani V, Ai X, et al.
Cell Chem Biol
. 2019 Oct;
27(1):32-40.e3.
PMID: 31653597
Proprotein convertase substilisin-like/kexin type 9 (PCSK9) is a serine protease involved in a protein-protein interaction with the low-density lipoprotein (LDL) receptor that has both human genetic and clinical validation. Blocking...
4.
Partridge A, Kaan H, Juang Y, Sadruddin A, Lim S, Brown C, et al.
Molecules
. 2019 Jun;
24(12).
PMID: 31226791
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical...
5.
Hopkins B, Lee H, Ha S, Nogle L, Sauvagnat B, McMinn S, et al.
ACS Med Chem Lett
. 2019 Jun;
10(6):874-879.
PMID: 31223441
As more macrocycle structures are utilized to drug intracellular targets, new platforms are needed to facilitate the discovery of cell permeable compounds in this unique chemical space. Herein, a method...
6.
Sawyer T, Partridge A, Kaan H, Juang Y, Lim S, Johannes C, et al.
Bioorg Med Chem
. 2018 Mar;
26(10):2807-2815.
PMID: 29598901
Macrocyclic α-helical peptides have emerged as a compelling new therapeutic modality to tackle targets confined to the intracellular compartment. Within the scope of hydrocarbon-stapling there has been significant progress to...
7.
Zhu Y, de Jesus R, Tang H, Walsh S, Jiang J, Gu X, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5695-5702.
PMID: 27839686
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors...
8.
Yang S, Pan J, Yang C, Labroli M, Pan W, Caldwell J, et al.
Bioorg Med Chem Lett
. 2016 Aug;
26(19):4743-4747.
PMID: 27575474
A series of benzimidazole analogs have been synthesized to improve the profile of the previous lead compounds tarocin B and 1. The syntheses, structure-activity relationships, and selected biochemical data of...
9.
Lee S, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, et al.
Sci Transl Med
. 2016 Mar;
8(329):329ra32.
PMID: 26962156
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S....
10.
Edmondson S, Zhu C, Kar N, Di Salvo J, Nagabukuro H, Sacre-Salem B, et al.
J Med Chem
. 2015 Dec;
59(2):609-23.
PMID: 26709102
The discovery of vibegron, a potent and selective human β3-AR agonist for the treatment of overactive bladder (OAB), is described. An early-generation clinical β3-AR agonist MK-0634 (3) exhibited efficacy in...