Sheo B Singh
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Explore the profile of Sheo B Singh including associated specialties, affiliations and a list of published articles.
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Articles
132
Citations
2010
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Recent Articles
1.
Singh S, Occi J, Ondeyka J, Barrett J, Masurekar P, Motyl M, et al.
J Antibiot (Tokyo)
. 2024 Aug;
77(10):679-684.
PMID: 39090325
Boxazomycins A-C are potent broad-spectrum antibiotics isolated from Actinomycetes strain G495-1 in 1987. We now report that boxazomycin A inhibits bacterial growth by selectively inhibiting protein synthesis, its effect is...
2.
Singh S, Martin G, McKittrick B, Crowther J, Fraenkel H, Lunn C, et al.
J Nat Prod
. 2024 Mar;
87(4):1235-1245.
PMID: 38554098
Research collaborations and licensing deals are critical for the discovery and development of life-saving drugs. This practice has been ongoing since the inception of the pharmaceutical industry. The current process...
3.
Singh S
Nat Prod Rep
. 2023 Nov;
41(2):298-322.
PMID: 38009216
Covering: 1982 to up to the end of 2022Bioassay guided purification of the extracts of led to the discovery of six series of combretastatins A-D with cytotoxic activities ranging from...
4.
Singh S, Tan C, Kaelin D, Meinke P, Miesel L, Olsen D, et al.
Bioorg Med Chem Lett
. 2022 May;
75:128808.
PMID: 35609741
Novel bacterial topoisomerase inhibitors (NBTIs) are the newest members of gyrase inhibitor broad-spectrum antibacterial agents, represented by the most advanced member, gepotidacin, a 4-amino-piperidine linked NBTI, which is undergoing phase...
5.
Singh S, Miesel L, Kramer S, Xu L, Li F, Lan J, et al.
J Nat Prod
. 2022 Apr;
85(4):1141-1146.
PMID: 35380836
is a commensal Gram-positive gut bacterium that causes -associated diarrhea. Currently available antibacterial therapeutic treatment options are effective except for the repeated recurrences significantly burdening the health care system and...
6.
Singh S
J Nat Prod
. 2022 Jan;
85(3):666-687.
PMID: 35072477
Dolastatin 10 is an extremely potent broad-spectrum antitubulin anticancer pentapeptide isolated from . The two-dimensional structure was elucidated by NMR and mass spectrometric analyses. The absolute configuration was determined by...
7.
Herath K, Previs S, Roddy T, Attygalle A, Gonzalez I, Genilloud O, et al.
J Nat Prod
. 2021 Feb;
84(3):814-823.
PMID: 33523676
Natural product congeners serve a useful role in the understanding of natural product biosynthesis and structure-activity relationships. A minor congener with superior activity, selectivity, and modifiable functional groups could serve...
8.
Singh S, Odingo J, Bailey M, Sunde B, Korkegian A, OMalley T, et al.
BMC Res Notes
. 2018 Jun;
11(1):416.
PMID: 29954459
Objective: Our aim was to identify natural products with anti-tubercular activity. Results: A set of ~ 500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium...
9.
Previs S, Herath K, Nawrocki A, Rodriguez C, Slipetz D, Singh S, et al.
Am J Physiol Endocrinol Metab
. 2018 Jan;
315(1):E63-E71.
PMID: 29351479
An increased contribution of de novo lipogenesis (DNL) may play a role in cases of dyslipidemia and adipose accretion; this suggests that inhibition of fatty acid synthesis may affect clinical...
10.
Singh S, Kang L, Nawrocki A, Zhou D, Wu M, Previs S, et al.
PLoS One
. 2017 Jan;
12(1):e0170721.
PMID: 28103304
[This corrects the article DOI: 10.1371/journal.pone.0164133.].