Sonsoles Velazquez
Overview
Explore the profile of Sonsoles Velazquez including associated specialties, affiliations and a list of published articles.
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50
Citations
252
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Recent Articles
1.
Hernandez-Ortiz N, Sanchez-Murcia P, Gil-Campillo C, Domenech M, Lucena-Agell D, Hortiguela R, et al.
Front Pharmacol
. 2024 Aug;
15:1428409.
PMID: 39156106
Cationic ultrashort lipopeptides (USLPs) are promising antimicrobial candidates to combat multidrug-resistant bacteria. Using DICAMs, a newly synthesized family of tripeptides with net charges from -2 to +1 and a fatty...
2.
Alcorlo M, Abdullah M, Steil L, Sotomayor F, Lopez-de Oro L, de Castro S, et al.
PLoS Pathog
. 2024 Jun;
20(6):e1011883.
PMID: 38838057
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of...
3.
de Lucio H, Revuelto A, Carriles A, de Castro S, Garcia-Gonzalez S, Garcia-Soriano J, et al.
Eur J Med Chem
. 2022 Nov;
244:114878.
PMID: 36332553
N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent inhibitors that target...
4.
Alcon-Calderon M, de Lucio H, Garcia-Soriano J, Revuelto A, de Castro S, Lopez-Gutierrez C, et al.
Eur J Med Chem
. 2022 Sep;
243:114675.
PMID: 36075146
Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypanothione disulfide...
5.
de Castro S, Stevaert A, Maldonado M, Delpal A, Vandeput J, Van Loy B, et al.
Pharmaceuticals (Basel)
. 2022 Aug;
15(8).
PMID: 36015168
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a...
6.
Hernandez S, Castanheira S, Pucciarelli M, Cestero J, Rico-Perez G, Paradela A, et al.
PLoS Pathog
. 2022 Jan;
18(1):e1010241.
PMID: 35077524
Salmonella enterica causes intracellular infections that can be limited to the intestine or spread to deeper tissues. In most cases, intracellular bacteria show moderate growth. How these bacteria face host...
7.
Revuelto A, Lopez-Martin I, de Lucio H, Garcia-Soriano J, Zanda N, de Castro S, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(7).
PMID: 34358115
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously...
8.
Revuelto A, de Lucio H, Garcia-Soriano J, Sanchez-Murcia P, Gago F, Jimenez-Ruiz A, et al.
J Med Chem
. 2021 May;
64(9):6137-6160.
PMID: 33945281
Inhibition of trypanothione disulfide reductase (TryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of...
9.
de Lucio H, Toro M, Camarasa M, Velazquez S, Gago F, Jimenez-Ruiz A
Br J Pharmacol
. 2020 Sep;
177(22):5163-5176.
PMID: 32888319
Background And Purpose: Peptide P4 was described as a dimerization disruptor of trypanothione reductase (TryR), a homodimeric enzyme essential for survival of trypanosomatids. Determination of the true inhibitory constant (K...
10.
Sanchez-Murcia P, de Castro S, Garcia-Aparicio C, Jimenez M, Corona A, Tramontano E, et al.
ACS Med Chem Lett
. 2020 May;
11(5):811-817.
PMID: 32435389
A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT...