Federico Gago
Overview
Explore the profile of Federico Gago including associated specialties, affiliations and a list of published articles.
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Articles
172
Citations
1407
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Recent Articles
1.
Menendez-Arias L, Gago F
Subcell Biochem
. 2024 Dec;
105:745-784.
PMID: 39738962
During the last forty years, significant progress has been made in the development of novel antiviral drugs, mainly crystallizing in the establishment of potent antiretroviral therapies and the approval of...
2.
Miguel-Ruano V, Acebron I, Lee M, Martin-Galiano A, Freton C, de Jose U, et al.
ACS Catal
. 2024 Dec;
14(24):18786-18798.
PMID: 39722888
Remodeling of the pneumococcal cell wall, carried out by peptidoglycan (PG) hydrolases, is imperative for maintaining bacterial cell shape and ensuring survival, particularly during cell division or stress response. The...
3.
Espaillat A, Alvarez L, Torrens G, Ter Beek J, Miguel-Ruano V, Irazoki O, et al.
Nat Commun
. 2024 Feb;
15(1):1343.
PMID: 38351082
The bacterial cell-wall peptidoglycan is made of glycan strands crosslinked by short peptide stems. Crosslinks are catalyzed by DD-transpeptidases (4,3-crosslinks) and LD-transpeptidases (3,3-crosslinks). However, recent research on non-model species has...
4.
Alcorlo M, Luque-Ortega J, Gago F, Ortega A, Castellanos M, Chacon P, et al.
Nucleic Acids Res
. 2024 Jan;
52(4):2045-2065.
PMID: 38281216
The genome-organizing protein p6 of Bacillus subtilis bacteriophage φ29 plays an essential role in viral development by activating the initiation of DNA replication and participating in the early-to-late transcriptional switch....
5.
Ma Y, Josa-Prado F, Essif J, Liu S, Li S, Lucena-Agell D, et al.
Eur J Med Chem
. 2023 Jul;
259:115668.
PMID: 37490800
The taxane class of microtubule stabilizers are some of the most effective and widely used chemotherapeutics. The anticancer activity of taxanes arises from their ability to induce tubulin assembly by...
6.
Martinez-Caballero S, Freton C, Molina R, Bartual S, Gueguen-Chaignon V, Mercy C, et al.
Cell Rep
. 2023 Jul;
42(7):112756.
PMID: 37418323
Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we...
7.
Prota A, Lucena-Agell D, Ma Y, Estevez-Gallego J, Li S, Bargsten K, et al.
Elife
. 2023 Mar;
12.
PMID: 36876916
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a...
8.
Marti-Mari O, Abdelnabi R, Schols D, Neyts J, Camarasa M, Gago F, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36834952
, the leading exponent of a class of potent HIV and enterovirus A71 (EV-A71) entry inhibitors discovered in our research group, contains four l-tryptophan (Trp) units bearing an aromatic isophthalic...
9.
Computational Approaches to Enzyme Inhibition by Marine Natural Products in the Search for New Drugs
Gago F
Mar Drugs
. 2023 Feb;
21(2).
PMID: 36827141
The exploration of biologically relevant chemical space for the discovery of small bioactive molecules present in marine organisms has led not only to important advances in certain therapeutic areas, but...
10.
Angela Oliva M, Gago F, Kamimura S, Fernando Diaz J
ACS Omega
. 2023 Feb;
8(4):3540-3550.
PMID: 36743020
Microtubules (MTs) are essential cellular machines built from concatenated αβ-tubulin heterodimers. They are responsible for two central and opposite functions from the dynamic point of view: scaffolding (static filaments) and...