Antonio Jimenez-Ruiz
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Explore the profile of Antonio Jimenez-Ruiz including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
490
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Recent Articles
1.
Garcia-Soriano J, de Lucio H, Elvira-Blazquez D, Alcon-Calderon M, Sanz Del Olmo N, Sanchez-Murcia P, et al.
J Enzyme Inhib Med Chem
. 2024 Jul;
39(1):2377586.
PMID: 39037009
Species of and genera are the causative agents of relevant parasitic diseases. Survival inside their hosts requires the existence of a potent antioxidant enzymatic machinery. Four iron superoxide dismutases have...
2.
Henriquez-Figuereo A, Alcon M, Moreno E, Sanmartin C, Espuelas S, de Lucio H, et al.
Bioorg Chem
. 2023 Jun;
138:106624.
PMID: 37295238
Nowadays, leishmaniasis is still treated with outdated drugs that present several obstacles related to their high toxicity, long duration, parenteral administration, high costs and drug resistance. Therefore, there is an...
3.
de Lucio H, Revuelto A, Carriles A, de Castro S, Garcia-Gonzalez S, Garcia-Soriano J, et al.
Eur J Med Chem
. 2022 Nov;
244:114878.
PMID: 36332553
N-methylation of the triazole moiety present in our recently described triazole-phenyl-thiazole dimerization disruptors of Leishmania infantum trypanothione disulfide reductase (LiTryR) led to a new class of potent inhibitors that target...
4.
Mesa-Arango J, Olave-Velandia A, Garcia-Montoya G, Isaza-Agudelo J, Jimenez-Ruiz A, Alzate J
Heliyon
. 2022 Oct;
8(10):e11144.
PMID: 36299519
Human toxocariasis is one of the neglected helminthiases and it is caused by the zoonotic roundworm species and . Diagnosis of human toxocariasis is based on the combination of clinical,...
5.
Alcon-Calderon M, de Lucio H, Garcia-Soriano J, Revuelto A, de Castro S, Lopez-Gutierrez C, et al.
Eur J Med Chem
. 2022 Sep;
243:114675.
PMID: 36075146
Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypanothione disulfide...
6.
de Lucio H, Garcia-Marin J, Sanchez-Alonso P, Garcia-Soriano J, Toro M, Vaquero J, et al.
Eur J Med Chem
. 2021 Oct;
227:113915.
PMID: 34695777
Fifteen pyridazino-pyrrolo-quinoxalinium salts were synthesized and tested for their antiprotozoal activity against Leishmania infantum amastigotes. Eleven of them turned out to be leishmanicidal, with EC values in the nanomolar range,...
7.
Revuelto A, Lopez-Martin I, de Lucio H, Garcia-Soriano J, Zanda N, de Castro S, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(7).
PMID: 34358115
Trypanothione disulfide reductase (TryR) is an essential homodimeric enzyme of trypanosomatid parasites that has been validated as a drug target to fight human infections. Using peptides and peptidomimetics, we previously...
8.
Etxebeste-Mitxeltorena M, Plano D, Espuelas S, Moreno E, Aydillo C, Jimenez-Ruiz A, et al.
Antimicrob Agents Chemother
. 2021 Aug;
65(10):e0059021.
PMID: 34339279
This work reports the synthesis and characterization by Fourier transform infrared spectroscopy (FTIR), H, C, and Se nuclear magnetic resonance (NMR), mass spectrometry, and elemental analysis techniques as well as...
9.
Revuelto A, de Lucio H, Garcia-Soriano J, Sanchez-Murcia P, Gago F, Jimenez-Ruiz A, et al.
J Med Chem
. 2021 May;
64(9):6137-6160.
PMID: 33945281
Inhibition of trypanothione disulfide reductase (TryR) by disruption of its homodimeric interface has proved to be an alternative and unexploited strategy in the search for novel antileishmanial agents. Proof of...
10.
Alcolea V, Moreno E, Etxebeste-Mitxeltorena M, Navarro-Blasco I, Gonzalez-Penas E, Jimenez-Ruiz A, et al.
Acta Trop
. 2020 Dec;
215:105801.
PMID: 33352169
Compounds 1 and 2 (selenocyanate and diselenide derivatives, respectively) were evaluated for their potential use in vivo against visceral leishmaniasis (VL). Both entities showed low cytoxicity in vitro in Vero...