Sivakama S Bharathi
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Explore the profile of Sivakama S Bharathi including associated specialties, affiliations and a list of published articles.
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21
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446
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Recent Articles
1.
Richert A, Zhang Y, Bharathi S, Hernandez A, Dodatko T, Bons J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990440
Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of...
2.
Chiba T, Oda A, Zhang Y, Pfister K, Bons J, Bharathi S, et al.
JCI Insight
. 2025 Feb;
PMID: 39932791
The renal tubular epithelial cells (RTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for RTECs via fatty acid oxidation (FAO), FAO-mediated...
3.
Zhang Y, Zhang B, Bharathi S, Bons J, Rose J, Shah S, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766215
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC)...
4.
Chiba T, Oda A, Zhang Y, Bons J, Bharathi S, Pfister K, et al.
bioRxiv
. 2024 Nov;
PMID: 39484612
Proximal tubular epithelial cells (PTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for PTECs via fatty acid oxidation (FAO), FAO-mediated H...
5.
Schmidt A, Bharathi S, Solo K, Bons J, Rose J, Schilling B, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334926
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but...
6.
Goetzman E, Zhang B, Zhang Y, Bharathi S, Bons J, Rose J, et al.
J Clin Invest
. 2024 Apr;
134(12).
PMID: 38687608
Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of...
7.
Bharathi S, Zhang B, Paul E, Zhang Y, Schmidt A, Fowler B, et al.
Mol Genet Metab
. 2022 Nov;
137(4):342-348.
PMID: 36335793
GM3 synthase (GM3S) deficiency is a rare neurodevelopmental disorder caused by an inability to synthesize gangliosides, for which there is currently no treatment. Gangliosides are brain-enriched, plasma membrane glycosphingolipids with...
8.
Jackson L, Kulkarni S, Wang H, Lu J, Dolezal J, Bharathi S, et al.
Cancer Res
. 2022 Mar;
82(5):944.
PMID: 35247896
No abstract available.
9.
Pereyra A, Harris K, Soepriatna A, Waterbury Q, Bharathi S, Zhang Y, et al.
J Lipid Res
. 2021 Mar;
62:100069.
PMID: 33757734
Long-chain fatty acid oxidation is frequently impaired in primary and systemic metabolic diseases affecting the heart; thus, therapeutically increasing reliance on normally minor energetic substrates, such as ketones and medium-chain...
10.
Goetzman E, Bharathi S, Zhang Y, Zhao X, Dobrowolski S, Peasley K, et al.
Sci Rep
. 2020 Oct;
10(1):18367.
PMID: 33110171
Medium-chain triglycerides (MCT), containing C-C fatty acids, are used to treat several pediatric disorders and are widely consumed as a nutritional supplement. Here, we investigated the role of the sirtuin...