Birgit Schilling
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Explore the profile of Birgit Schilling including associated specialties, affiliations and a list of published articles.
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189
Citations
7313
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Recent Articles
1.
Richert A, Zhang Y, Bharathi S, Hernandez A, Dodatko T, Bons J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990440
Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of...
2.
Chiba T, Oda A, Zhang Y, Pfister K, Bons J, Bharathi S, et al.
JCI Insight
. 2025 Feb;
PMID: 39932791
The renal tubular epithelial cells (RTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for RTECs via fatty acid oxidation (FAO), FAO-mediated...
3.
Burton J, Gascard P, Pan D, Bons J, Bai R, Chen-Tanyolac C, et al.
bioRxiv
. 2025 Feb;
PMID: 39896465
Breast cancer manifests as multiple subtypes with distinct patient outcomes and treatment strategies. Here, we optimized proteomic analysis of Formalin-Fixed Paraffin-Embedded (FFPE) specimens from patients diagnosed with five breast cancer...
4.
Du H, Rose J, Bons J, Guo L, Valentino T, Wu F, et al.
Geroscience
. 2025 Jan;
PMID: 39826027
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an...
5.
Zhang Y, Zhang B, Bharathi S, Bons J, Rose J, Shah S, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766215
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC)...
6.
Begelman D, Dixit B, Truong C, King C, Watson M, Schilling B, et al.
Mol Ther Methods Clin Dev
. 2024 Dec;
32(4):101372.
PMID: 39659757
Replicative errors, inefficient repair, and proximity to sites of reactive oxygen species production make mitochondrial DNA (mtDNA) susceptible to damage with time. We explore allotopic expression (re-engineering mitochondrial genes and...
7.
Madhavan S, Diaz S, Peralta S, Nomura M, King C, Ceyhan K, et al.
Cell Chem Biol
. 2024 Dec;
32(1):174-191.e8.
PMID: 39626664
Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate...
8.
Du H, Rose J, Bons J, Guo L, Valentino T, Wu F, et al.
bioRxiv
. 2024 Nov;
PMID: 39605579
Cells are subjected to dynamic mechanical environments which impart forces and induce cellular responses. In age-related conditions like pulmonary fibrosis, there is both an increase in tissue stiffness and an...
9.
Chiba T, Oda A, Zhang Y, Bons J, Bharathi S, Pfister K, et al.
bioRxiv
. 2024 Nov;
PMID: 39484612
Proximal tubular epithelial cells (PTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for PTECs via fatty acid oxidation (FAO), FAO-mediated H...
10.
Schmidt A, Bharathi S, Solo K, Bons J, Rose J, Schilling B, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334926
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but...